Tissue expression of MTIF2 - Summary - The Human Protein Atlas

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MTIF2

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MTIF2
Gene description	Mitochondrial translational initiation factor 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues including cilia and positivity in a subsets of immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA006021
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

N/A

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MTIF2 (HGNC Symbol)
Synonyms	IF-2mt
Description	Mitochondrial translational initiation factor 2 (HGNC Symbol)
Entrez gene summary	During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p16.1
Chromosome location (bp)	55236595 - 55269347
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000085760 (version 83.38)
Entrez gene	4528
UniProt	P46199 (UniProt - Evidence at protein level)
neXtProt	NX_P46199
Antibodypedia	MTIF2 antibodies

PROTEIN BROWSER

MTIF2-001	MTIF2-002	MTIF2-005	MTIF2-007	MTIF2-008	MTIF2-009	MTIF2-010	MTIF2-011	MTIF2-012	MTIF2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTIF2-001 ENSP00000263629 ENST00000263629	P46199 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0006996 [organelle organization] GO:0008135 [translation factor activity, RNA binding] GO:0032543 [mitochondrial translation] GO:0032790 [ribosome disassembly] GO:0043024 [ribosomal small subunit binding] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] Show all	727 aa 81.3 kDa	No	0
MTIF2-002 ENSP00000384481 ENST00000403721	P46199 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0006996 [organelle organization] GO:0008135 [translation factor activity, RNA binding] GO:0032543 [mitochondrial translation] GO:0032790 [ribosome disassembly] GO:0043024 [ribosomal small subunit binding] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] Show all	727 aa 81.3 kDa	No	0
MTIF2-005 ENSP00000393337 ENST00000366137	E7EW07 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 8.6 kDa	No	0
MTIF2-007 ENSP00000388640 ENST00000441307	A0A0E3D6N0 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 8.5 kDa	No	0
MTIF2-008 ENSP00000416057 ENST00000420637	C9JIY5 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 3.2 kDa	No	0
MTIF2-009 ENSP00000383880 ENST00000404297	B5MCU1 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 8.4 kDa	No	0
MTIF2-010 ENSP00000403492 ENST00000418823	H7C213 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		301 aa 33.5 kDa	No	0
MTIF2-011 ENSP00000393025 ENST00000412530		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		7 aa 0.9 kDa	No	0
MTIF2-012 ENSP00000399531 ENST00000417363		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.2 kDa	No	0
MTIF2-201 ENSP00000378099 ENST00000394600	P46199 [Direct mapping] Translation initiation factor IF-2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0003924 [GTPase activity] GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006413 [translational initiation] GO:0006446 [regulation of translational initiation] GO:0006996 [organelle organization] GO:0008135 [translation factor activity, RNA binding] GO:0032543 [mitochondrial translation] GO:0032790 [ribosome disassembly] GO:0043024 [ribosomal small subunit binding] GO:0044822 [poly(A) RNA binding] GO:0070124 [mitochondrial translational initiation] Show all	727 aa 81.3 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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