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Gene name

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In atlas

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Method

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Searches

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Detectable

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MTIF2
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MTIF2

Gene description

Mitochondrial translational initiation factor 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues including cilia and positivity in a subsets of immune cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA006021
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
N/A
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
N/ACerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin010203040TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin024681012RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0102030405060Tags Per Million

GENE INFORMATION

Gene name

MTIF2 (HGNC Symbol)

Synonyms

IF-2mt

Description

Mitochondrial translational initiation factor 2 (HGNC Symbol)

Entrez gene summary

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p16.1

Chromosome location (bp)

55236595 - 55269347

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000085760 (version 83.38)

Entrez gene

4528

UniProt

P46199 (UniProt - Evidence at protein level)

neXtProt

NX_P46199

Antibodypedia

MTIF2 antibodies

PROTEIN BROWSER

MTIF2-001
MTIF2-002
MTIF2-005
MTIF2-007
MTIF2-008
MTIF2-009
MTIF2-010
MTIF2-011
MTIF2-012
MTIF2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MTIF2-001
ENSP00000263629
ENST00000263629
P46199 [Direct mapping]
Translation initiation factor IF-2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0006996 [organelle organization]
GO:0008135 [translation factor activity, RNA binding]
GO:0032543 [mitochondrial translation]
GO:0032790 [ribosome disassembly]
GO:0043024 [ribosomal small subunit binding]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
Show all
727 aa
81.3 kDa
No 0
MTIF2-002
ENSP00000384481
ENST00000403721
P46199 [Direct mapping]
Translation initiation factor IF-2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0006996 [organelle organization]
GO:0008135 [translation factor activity, RNA binding]
GO:0032543 [mitochondrial translation]
GO:0032790 [ribosome disassembly]
GO:0043024 [ribosomal small subunit binding]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
Show all
727 aa
81.3 kDa
No 0
MTIF2-005
ENSP00000393337
ENST00000366137
E7EW07 [Direct mapping]
Translation initiation factor IF-2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
72 aa
8.6 kDa
No 0
MTIF2-007
ENSP00000388640
ENST00000441307
A0A0E3D6N0 [Direct mapping]
Translation initiation factor IF-2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
71 aa
8.5 kDa
No 0
MTIF2-008
ENSP00000416057
ENST00000420637
C9JIY5 [Direct mapping]
Translation initiation factor IF-2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
26 aa
3.2 kDa
No 0
MTIF2-009
ENSP00000383880
ENST00000404297
B5MCU1 [Direct mapping]
Translation initiation factor IF-2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
70 aa
8.4 kDa
No 0
MTIF2-010
ENSP00000403492
ENST00000418823
H7C213 [Direct mapping]
Translation initiation factor IF-2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
301 aa
33.5 kDa
No 0
MTIF2-011
ENSP00000393025
ENST00000412530
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
7 aa
0.9 kDa
No 0
MTIF2-012
ENSP00000399531
ENST00000417363
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
10 aa
1.2 kDa
No 0
MTIF2-201
ENSP00000378099
ENST00000394600
P46199 [Direct mapping]
Translation initiation factor IF-2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0006996 [organelle organization]
GO:0008135 [translation factor activity, RNA binding]
GO:0032543 [mitochondrial translation]
GO:0032790 [ribosome disassembly]
GO:0043024 [ribosomal small subunit binding]
GO:0044822 [poly(A) RNA binding]
GO:0070124 [mitochondrial translational initiation]
Show all
727 aa
81.3 kDa
No 0

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