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Most tumors showed nuclear and cytoplasmic positivity of moderate intensity. Testicular cancers and a few urothelial- and breast cancers were strongly positive.
A majority of the cancer tissues showed weak cytoplasmic and sometimes nuclear staining or were negative. Moderate positivity was seen in a majority of testicular cancers and a few cases of colorectal, breast and prostate cancers.
GENE INFORMATION
Gene name
HUWE1 (HGNC Symbol)
Synonyms
Ib772, KIAA0312, UREB1
Description
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013]
