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MYBPC2

GENERAL INFORMATION

Gene name

 MYBPC2

Gene description

 Myosin binding protein C, fast type

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (skeletal muscle, parathyroid gland)
GTEx:Tissue enriched (skeletal muscle)
FANTOM5:Group enriched (skeletal muscle, epididymis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of skeletal muscle cells.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA042991 , HPA046745
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, epididymis)

GENE INFORMATION

Gene name

 MYBPC2 (HGNC Symbol)

Synonyms

 MGC163408, MYBPC, MYBPCF

Description

 Myosin binding protein C, fast type (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform. Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively. [provided by RefSeq, Jul 2012]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 50432903 - 50466321

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000086967 (version 83.38)

Entrez gene

 4606

UniProt

 Q14324 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14324

Antibodypedia

 MYBPC2 antibodies

PROTEIN BROWSER
MYBPC2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYBPC2-001
ENSP00000350332
ENST00000357701
Q14324 [Direct mapping]
Myosin-binding protein C, fast-type
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0007155 [cell adhesion]
GO:0008307 [structural constituent of muscle]
GO:0030049 [muscle filament sliding]
GO:0032982 [myosin filament]
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 1141 aa
128.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.