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A few cases of melanomas, lung, skin and urothelial cancer displayed moderate to strong cytoplasmic or nuclear positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
ACOX3
Synonyms
Description
Acyl-CoA oxidase 3, pristanoyl (HGNC Symbol)
Entrez gene summary
Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]
O15254 [Direct mapping] Peroxisomal acyl-coenzyme A oxidase 3
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Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000062 [fatty-acyl-CoA binding] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0003997 [acyl-CoA oxidase activity] GO:0005102 [receptor binding] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006631 [fatty acid metabolic process] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016020 [membrane] GO:0016402 [pristanoyl-CoA oxidase activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process]
O15254 [Direct mapping] Peroxisomal acyl-coenzyme A oxidase 3
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Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0003997 [acyl-CoA oxidase activity] GO:0005102 [receptor binding] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006631 [fatty acid metabolic process] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016020 [membrane] GO:0016402 [pristanoyl-CoA oxidase activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process]
D6RJ89 [Direct mapping] Peroxisomal acyl-coenzyme A oxidase 3
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003995 [acyl-CoA dehydrogenase activity] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0055114 [oxidation-reduction process]
