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Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]
O15254 [Direct mapping] Peroxisomal acyl-coenzyme A oxidase 3
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Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000062 [fatty-acyl-CoA binding] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0003997 [acyl-CoA oxidase activity] GO:0005102 [receptor binding] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006631 [fatty acid metabolic process] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016020 [membrane] GO:0016402 [pristanoyl-CoA oxidase activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process]
O15254 [Direct mapping] Peroxisomal acyl-coenzyme A oxidase 3
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Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000062 [fatty-acyl-CoA binding] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0003997 [acyl-CoA oxidase activity] GO:0005102 [receptor binding] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006631 [fatty acid metabolic process] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016020 [membrane] GO:0016402 [pristanoyl-CoA oxidase activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process]
D6RJ89 [Direct mapping] Peroxisomal acyl-coenzyme A oxidase 3
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0003995 [acyl-CoA dehydrogenase activity] GO:0008152 [metabolic process] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0055114 [oxidation-reduction process]
