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TRIP6

CANCER ATLAS

Gene description

 Thyroid hormone receptor interactor 6

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA052813
CAB046454
CAB046460

GENE INFORMATION

Gene name

 TRIP6 (HGNC Symbol)

Synonyms

 MGC10556, MGC10558, MGC29959, MGC3837, MGC4423, OIP1, ZRP-1

Description

 Thyroid hormone receptor interactor 6 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100867138 - 100873454

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087077 (version 83.38)

Entrez gene

 7205

UniProt

 Q15654 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15654

Antibodypedia

 TRIP6 antibodies

PROTEIN BROWSER
TRIP6-001
TRIP6-009
TRIP6-201
TRIP6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIP6-001
ENSP00000200457
ENST00000200457
Q15654 [Direct mapping]
Thyroid receptor-interacting protein 6
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0008588 [release of cytoplasmic sequestered NF-kappaB]
GO:0019900 [kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045323 [interleukin-1 receptor complex]
GO:0046966 [thyroid hormone receptor binding]
GO:0048041 [focal adhesion assembly]
Show all
 476 aa
50.3 kDa 		No 0
TRIP6-009
ENSP00000389194
ENST00000429658
H7BZE2 [Direct mapping]
Thyroid receptor-interacting protein 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 216 aa
23.1 kDa 		No 0
TRIP6-201
ENSP00000479865
ENST00000619988
Q15654 [Direct mapping]
Thyroid receptor-interacting protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0008588 [release of cytoplasmic sequestered NF-kappaB]
GO:0019900 [kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045323 [interleukin-1 receptor complex]
GO:0046966 [thyroid hormone receptor binding]
GO:0048041 [focal adhesion assembly]
Show all
 80 aa
8.3 kDa 		No 0
TRIP6-202
ENSP00000486847
ENST00000629911
A0A0D9SFS2 [Direct mapping]
Thyroid receptor-interacting protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 339 aa
35.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.