Fields »
ABOUT
HELP
BLOG
TRIP6

GENERAL INFORMATION

Gene name

 TRIP6

Gene description

 Thyroid hormone receptor interactor 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA052813 , CAB046454 , CAB046460
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRIP6 (HGNC Symbol)

Synonyms

 MGC10556, MGC10558, MGC29959, MGC3837, MGC4423, OIP1, ZRP-1

Description

 Thyroid hormone receptor interactor 6 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100867138 - 100873454

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087077 (version 83.38)

Entrez gene

 7205

UniProt

 Q15654 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15654

Antibodypedia

 TRIP6 antibodies

PROTEIN BROWSER
TRIP6-001
TRIP6-009
TRIP6-201
TRIP6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIP6-001
ENSP00000200457
ENST00000200457
Q15654 [Direct mapping]
Thyroid receptor-interacting protein 6
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0008588 [release of cytoplasmic sequestered NF-kappaB]
GO:0019900 [kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045323 [interleukin-1 receptor complex]
GO:0046966 [thyroid hormone receptor binding]
GO:0048041 [focal adhesion assembly]
Show all
 476 aa
50.3 kDa 		No 0
TRIP6-009
ENSP00000389194
ENST00000429658
H7BZE2 [Direct mapping]
Thyroid receptor-interacting protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 216 aa
23.1 kDa 		No 0
TRIP6-201
ENSP00000479865
ENST00000619988
Q15654 [Direct mapping]
Thyroid receptor-interacting protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0008588 [release of cytoplasmic sequestered NF-kappaB]
GO:0019900 [kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045323 [interleukin-1 receptor complex]
GO:0046966 [thyroid hormone receptor binding]
GO:0048041 [focal adhesion assembly]
Show all
 80 aa
8.3 kDa 		No 0
TRIP6-202
ENSP00000486847
ENST00000629911
A0A0D9SFS2 [Direct mapping]
Thyroid receptor-interacting protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 339 aa
35.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.