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GNAS

CANCER ATLAS

Gene description

 GNAS complex locus

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA018122
HPA027478
HPA028386
CAB010337

GENE INFORMATION

Gene name

 GNAS (HGNC Symbol)

Synonyms

 GNAS1, GNASXL, GPSA, NESP, NESP55, SCG6, SgVI

Description

 GNAS complex locus (HGNC Symbol)

Entrez gene summary

 This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]

Chromosome

 20

Cytoband

 q13.32

Chromosome location (bp)

 58839718 - 58911192

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000087460 (version 83.38)

Entrez gene

 2778

UniProt

 O95467 (UniProt - Evidence at transcript level), P63092 (UniProt - Evidence at protein level), P84996 (UniProt - Evidence at protein level), Q5JWF2 (UniProt - Evidence at protein level)

neXtProt

 NX_O95467, NX_P63092, NX_P84996, NX_Q5JWF2

Antibodypedia

 GNAS antibodies

PROTEIN BROWSER
«
GNAS-001
GNAS-002
GNAS-009
GNAS-014
GNAS-015
GNAS-017
GNAS-018
GNAS-021
GNAS-022
GNAS-023
GNAS-025
GNAS-035
GNAS-036
GNAS-037
GNAS-038
GNAS-049
GNAS-050
GNAS-058
GNAS-063
GNAS-071
GNAS-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNAS-001
ENSP00000360141
ENST00000371100
Q5JWF2 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001894 [tissue homeostasis]
GO:0001958 [endochondral ossification]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0006112 [energy reserve metabolic process]
GO:0006306 [DNA methylation]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0009791 [post-embryonic development]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030425 [dendrite]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0035264 [multicellular organism growth]
GO:0040032 [post-embryonic body morphogenesis]
GO:0042493 [response to drug]
GO:0043588 [skin development]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0046872 [metal ion binding]
GO:0048589 [developmental growth]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0050890 [cognition]
GO:0051216 [cartilage development]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0060348 [bone development]
GO:0060789 [hair follicle placode formation]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0071514 [genetic imprinting]
Show all
 1037 aa
111 kDa 		No 0
GNAS-002
ENSP00000323571
ENST00000313949
O95467 [Direct mapping]
Neuroendocrine secretory protein 55 LHAL tetrapeptide GPIPIRRH peptide
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0007606 [sensory perception of chemical stimulus]
GO:0009306 [protein secretion]
GO:0030133 [transport vesicle]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0040015 [negative regulation of multicellular organism growth]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0071107 [response to parathyroid hormone]
Show all
 245 aa
28 kDa 		Yes 0
GNAS-009
ENSP00000360143
ENST00000371102
Q5JWF2 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0046872 [metal ion binding]
GO:0048589 [developmental growth]
GO:0050890 [cognition]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0060348 [bone development]
GO:0060789 [hair follicle placode formation]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
Show all
 1023 aa
109.6 kDa 		No 0
GNAS-014
ENSP00000360115
ENST00000371075
O95467 [Direct mapping]
Neuroendocrine secretory protein 55 LHAL tetrapeptide GPIPIRRH peptide
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0007606 [sensory perception of chemical stimulus]
GO:0009306 [protein secretion]
GO:0030133 [transport vesicle]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0040015 [negative regulation of multicellular organism growth]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0071107 [response to parathyroid hormone]
Show all
 245 aa
28 kDa 		Yes 0
GNAS-015
ENSP00000360126
ENST00000371085
P63092 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003924 [GTPase activity]
GO:0004016 [adenylate cyclase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007608 [sensory perception of smell]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031224 [intrinsic component of membrane]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0032588 [trans-Golgi network membrane]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046907 [intracellular transport]
GO:0048589 [developmental growth]
GO:0050796 [regulation of insulin secretion]
GO:0050890 [cognition]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0055085 [transmembrane transport]
GO:0060348 [bone development]
GO:0060789 [hair follicle placode formation]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 394 aa
45.7 kDa 		No 0
GNAS-017
ENSP00000360136
ENST00000371095
P63092 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003924 [GTPase activity]
GO:0004016 [adenylate cyclase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007608 [sensory perception of smell]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031224 [intrinsic component of membrane]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0032588 [trans-Golgi network membrane]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046907 [intracellular transport]
GO:0048589 [developmental growth]
GO:0050796 [regulation of insulin secretion]
GO:0050890 [cognition]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0055085 [transmembrane transport]
GO:0060348 [bone development]
GO:0060789 [hair follicle placode formation]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 380 aa
44.3 kDa 		No 0
GNAS-018
ENSP00000346328
ENST00000354359
P63092 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003924 [GTPase activity]
GO:0004016 [adenylate cyclase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007608 [sensory perception of smell]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031224 [intrinsic component of membrane]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0032588 [trans-Golgi network membrane]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046907 [intracellular transport]
GO:0048589 [developmental growth]
GO:0050796 [regulation of insulin secretion]
GO:0050890 [cognition]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0055085 [transmembrane transport]
GO:0060348 [bone development]
GO:0060789 [hair follicle placode formation]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 395 aa
45.8 kDa 		No 0
GNAS-021
ENSP00000345971
ENST00000338783
A2A2R6 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
Show all
 61 aa
7 kDa 		No 0
GNAS-022
ENSP00000392000
ENST00000453292
A2A2S1 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0071107 [response to parathyroid hormone]
Show all
 166 aa
19 kDa 		No 0
GNAS-023
ENSP00000416234
ENST00000419558
H0Y7Z6 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0071107 [response to parathyroid hormone]
Show all
 113 aa
12.7 kDa 		No 0
GNAS-025
ENSP00000360139
ENST00000371098
O95467 [Direct mapping]
Neuroendocrine secretory protein 55 LHAL tetrapeptide GPIPIRRH peptide
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007565 [female pregnancy]
GO:0007606 [sensory perception of chemical stimulus]
GO:0009306 [protein secretion]
GO:0030133 [transport vesicle]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0040015 [negative regulation of multicellular organism growth]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0071107 [response to parathyroid hormone]
Show all
 245 aa
28 kDa 		Yes 0
GNAS-035
ENSP00000265620
ENST00000265620
P63092 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003924 [GTPase activity]
GO:0004016 [adenylate cyclase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006171 [cAMP biosynthetic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0007606 [sensory perception of chemical stimulus]
GO:0007608 [sensory perception of smell]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031224 [intrinsic component of membrane]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0032588 [trans-Golgi network membrane]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0043547 [positive regulation of GTPase activity]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046907 [intracellular transport]
GO:0048589 [developmental growth]
GO:0050796 [regulation of insulin secretion]
GO:0050890 [cognition]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0055085 [transmembrane transport]
GO:0060348 [bone development]
GO:0060789 [hair follicle placode formation]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0071377 [cellular response to glucagon stimulus]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071870 [cellular response to catecholamine stimulus]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
 379 aa
44.2 kDa 		No 0
GNAS-036
ENSP00000412424
ENST00000450130
H0Y7F4 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
Show all
 199 aa
22.7 kDa 		No 0
GNAS-037
ENSP00000265621
ENST00000349036
Q5JWE9 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
Show all
 193 aa
21.9 kDa 		No 0
GNAS-038
ENSP00000360122
ENST00000371081
Q5JWD1 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
Show all
 87 aa
9.6 kDa 		No 0
GNAS-049
ENSP00000412356
ENST00000423897
H0Y7E8 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
Show all
 93 aa
10.4 kDa 		No 0
GNAS-050
ENSP00000302237
ENST00000306120
P84996 [Direct mapping]
Protein ALEX
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0009966 [regulation of signal transduction]
GO:0016020 [membrane]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0048589 [developmental growth]
GO:0050890 [cognition]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
GO:0060348 [bone development]
GO:0060789 [hair follicle placode formation]
GO:0070527 [platelet aggregation]
Show all
 625 aa
67.8 kDa 		No 0
GNAS-058
ENSP00000360140
ENST00000371099
X6R7U9 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
Show all
 720 aa
74.3 kDa 		No 0
GNAS-063
ENSP00000474802
ENST00000603546
S4R3V9 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
Show all
 120 aa
13.6 kDa 		No 0
GNAS-071
ENSP00000474219
ENST00000604005
S4R3E3 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
Show all
 160 aa
18.3 kDa 		No 0
GNAS-201
ENSP00000304472
ENST00000306090
A0A0A0MR13 [Direct mapping]
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005525 [GTP binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0031748 [D1 dopamine receptor binding]
GO:0031852 [mu-type opioid receptor binding]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0051430 [corticotropin-releasing hormone receptor 1 binding]
Show all
 158 aa
18.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.