Cell atlas - SLC15A1 - The Human Protein Atlas

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SLC15A1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SLC15A1
Gene description	Solute carrier family 15 (oligopeptide transporter), member 1
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Group enriched (CAPAN-2, SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA002827
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (CAPAN-2, SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002827	CACO-2	Nucleoplasm
	HPA002827	U-2 OS	Nucleoplasm
	HPA002827	U-2 OS	Cytosol
	HPA002827	U-251 MG	Nucleoplasm
	HPA002827	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SLC15A1 (HGNC Symbol)
Synonyms	HPECT1, HPEPT1, PEPT1
Description	Solute carrier family 15 (oligopeptide transporter), member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]
Chromosome	13
Cytoband
Chromosome location (bp)	98683801 - 98752654
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000088386 (version 83.38)
Entrez gene	6564
UniProt	P46059 (UniProt - Evidence at transcript level)
neXtProt	NX_P46059
Antibodypedia	SLC15A1 antibodies

PROTEIN BROWSER

SLC15A1-001	SLC15A1-201	SLC15A1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC15A1-001 ENSP00000365686 ENST00000376503	P46059 [Direct mapping] Solute carrier family 15 member 1 B2CQT6 [Target identity:100%; Query identity:100%] Solute carrier family 15 oligopeptide transporter member 1 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005215 [transporter activity] GO:0005427 [proton-dependent oligopeptide secondary active transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005903 [brush border] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006857 [oligopeptide transport] GO:0007586 [digestion] GO:0015031 [protein transport] GO:0015198 [oligopeptide transporter activity] GO:0015333 [peptide:proton symporter activity] GO:0015992 [proton transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035672 [oligopeptide transmembrane transport] GO:0055085 [transmembrane transport] Show all	708 aa 78.8 kDa	No	>9
SLC15A1-201 ENSP00000482440 ENST00000613008	O14496 [Direct mapping] Solute carrier family 15 member 1; pH-sensing regulatory factor of peptide transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005215 [transporter activity] GO:0005575 [cellular_component] GO:0006810 [transport] GO:0006857 [oligopeptide transport] GO:0015833 [peptide transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	208 aa 23.1 kDa	No	7
SLC15A1-202 ENSP00000478051 ENST00000618992	A0A087WTQ1 [Direct mapping] Solute carrier family 15 member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0006857 [oligopeptide transport] GO:0015198 [oligopeptide transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	706 aa 78.6 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.