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Several cases of hepatocellular carcinomas and cervical squamous cell carcinomas exhibited moderate to strong cytoplasmic and nuclear staining while ductal breast carcinomas and malignant carcinoids displayed cytoplasmic positivity. Cases of urothelial cancers showed moderate to strong nuclear positivity. Remaining malignant cells were in general weakly stained or negative.
Most malignant melanomas, thyroid and lung cancers as well as cases of ovarian and endometrial cancers showed weak to moderate nuclear and cytoplasmic positivity. Remaining malignant cells were generally negative.
GENE INFORMATION
Gene name
TGDS (HGNC Symbol)
Synonyms
SDR2E1, TDPGD
Description
TDP-glucose 4,6-dehydratase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
