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MAVS

GENERAL INFORMATION

Gene name

 MAVS

Gene description

 Mitochondrial antiviral signaling protein

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA049850 , HPA053524 , CAB009187
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAVS (HGNC Symbol)

Synonyms

 Cardif, IPS-1, KIAA1271, VISA

Description

 Mitochondrial antiviral signaling protein (HGNC Symbol)

Entrez gene summary

 This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3846799 - 3876123

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000088888 (version 83.38)

Entrez gene

 57506

UniProt

 Q7Z434 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z434

Antibodypedia

 MAVS antibodies

PROTEIN BROWSER
MAVS-001
MAVS-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAVS-001
ENSP00000401980
ENST00000428216
Q7Z434 [Direct mapping]
Mitochondrial antiviral-signaling protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002218 [activation of innate immune response]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0007165 [signal transduction]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0031966 [mitochondrial membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0039529 [RIG-I signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050700 [CARD domain binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051607 [defense response to virus]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071651 [positive regulation of chemokine (C-C motif) ligand 5 production]
GO:0071660 [positive regulation of IP-10 production]
GO:1900063 [regulation of peroxisome organization]
Show all
 540 aa
56.5 kDa 		No 1
MAVS-201
ENSP00000413749
ENST00000416600
Q7Z434 [Direct mapping]
Mitochondrial antiviral-signaling protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002218 [activation of innate immune response]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005778 [peroxisomal membrane]
GO:0007165 [signal transduction]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0031966 [mitochondrial membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033160 [positive regulation of protein import into nucleus, translocation]
GO:0042742 [defense response to bacterium]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050700 [CARD domain binding]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051607 [defense response to virus]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071651 [positive regulation of chemokine (C-C motif) ligand 5 production]
GO:0071660 [positive regulation of IP-10 production]
GO:1900063 [regulation of peroxisome organization]
Show all
 399 aa
40.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.