Expression of SLC23A2 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 23 (ascorbic acid transporter), member 2

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA052825

GENE INFORMATION
Gene name	SLC23A2 (HGNC Symbol)
Synonyms	KIAA0238, SLC23A1, SVCT2, YSPL2
Description	Solute carrier family 23 (ascorbic acid transporter), member 2 (HGNC Symbol)
Entrez gene summary	The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	4852356 - 5010293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089057 (version 83.38)
Entrez gene	9962
UniProt	Q9UGH3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGH3
Antibodypedia	SLC23A2 antibodies

PROTEIN BROWSER

SLC23A2-001	SLC23A2-002	SLC23A2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC23A2-001 ENSP00000368637 ENST00000379333	Q9UGH3 [Direct mapping] Solute carrier family 23 member 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006979 [response to oxidative stress] GO:0008523 [sodium-dependent multivitamin transmembrane transporter activity] GO:0009925 [basal plasma membrane] GO:0015205 [nucleobase transmembrane transporter activity] GO:0015229 [L-ascorbic acid transporter activity] GO:0015851 [nucleobase transport] GO:0015882 [L-ascorbic acid transport] GO:0015993 [molecular hydrogen transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019852 [L-ascorbic acid metabolic process] GO:0035461 [vitamin transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity] GO:0070904 [transepithelial L-ascorbic acid transport] Show all	650 aa 70.3 kDa	No	>9
SLC23A2-002 ENSP00000344322 ENST00000338244	Q9UGH3 [Direct mapping] Solute carrier family 23 member 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0008523 [sodium-dependent multivitamin transmembrane transporter activity] GO:0015205 [nucleobase transmembrane transporter activity] GO:0015229 [L-ascorbic acid transporter activity] GO:0015851 [nucleobase transport] GO:0015882 [L-ascorbic acid transport] GO:0015993 [molecular hydrogen transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019852 [L-ascorbic acid metabolic process] GO:0035461 [vitamin transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity] GO:0070904 [transepithelial L-ascorbic acid transport] Show all	650 aa 70.3 kDa	No	>9
SLC23A2-004 ENSP00000396364 ENST00000423430	H0Y544 [Direct mapping] Solute carrier family 23 member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0015882 [L-ascorbic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035461 [vitamin transmembrane transport] GO:0055085 [transmembrane transport] GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity] Show all	304 aa 32.8 kDa	No	6