Cell atlas - SLC23A2 - The Human Protein Atlas

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SLC23A2

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	SLC23A2
Gene description	Solute carrier family 23 (ascorbic acid transporter), member 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Additional location	In addition localized to the Golgi apparatus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA059314
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the Golgi apparatus.

Main location

Vesicles (supported)

Additional location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059314	A-431	Golgi apparatus
	HPA059314	A-431	Vesicles
	HPA059314	Hep G2	No staining
	HPA059314	U-2 OS	Vesicles

GENE INFORMATION
Gene name	SLC23A2 (HGNC Symbol)
Synonyms	KIAA0238, SLC23A1, SVCT2, YSPL2
Description	Solute carrier family 23 (ascorbic acid transporter), member 2 (HGNC Symbol)
Entrez gene summary	The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	4852356 - 5010293
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089057 (version 83.38)
Entrez gene	9962
UniProt	Q9UGH3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGH3
Antibodypedia	SLC23A2 antibodies

PROTEIN BROWSER

SLC23A2-001	SLC23A2-002	SLC23A2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC23A2-001 ENSP00000368637 ENST00000379333	Q9UGH3 [Direct mapping] Solute carrier family 23 member 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0006979 [response to oxidative stress] GO:0008523 [sodium-dependent multivitamin transmembrane transporter activity] GO:0009925 [basal plasma membrane] GO:0015205 [nucleobase transmembrane transporter activity] GO:0015229 [L-ascorbic acid transporter activity] GO:0015851 [nucleobase transport] GO:0015882 [L-ascorbic acid transport] GO:0015993 [molecular hydrogen transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019852 [L-ascorbic acid metabolic process] GO:0035461 [vitamin transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity] GO:0070904 [transepithelial L-ascorbic acid transport] Show all	650 aa 70.3 kDa	No	>9
SLC23A2-002 ENSP00000344322 ENST00000338244	Q9UGH3 [Direct mapping] Solute carrier family 23 member 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0008523 [sodium-dependent multivitamin transmembrane transporter activity] GO:0015205 [nucleobase transmembrane transporter activity] GO:0015229 [L-ascorbic acid transporter activity] GO:0015851 [nucleobase transport] GO:0015882 [L-ascorbic acid transport] GO:0015993 [molecular hydrogen transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019852 [L-ascorbic acid metabolic process] GO:0035461 [vitamin transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity] GO:0070904 [transepithelial L-ascorbic acid transport] Show all	650 aa 70.3 kDa	No	>9
SLC23A2-004 ENSP00000396364 ENST00000423430	H0Y544 [Direct mapping] Solute carrier family 23 member 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0015882 [L-ascorbic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035461 [vitamin transmembrane transport] GO:0055085 [transmembrane transport] GO:0070890 [sodium-dependent L-ascorbate transmembrane transporter activity] Show all	304 aa 32.8 kDa	No	6

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.