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A majority of colorectal, prostate, endometrial and pancreatic cancers as well as several breast, ovarian, cervical, stomach and liver cancers showed moderate cytoplasmic staining. The remaining cancer cells were weakly stained or negative.
Several cases of colorectal, testicular and female genital cancers displayed weak to moderate cytoplasmic immunoreactivity. The remaining cancer tissues were mainly negative.
GENE INFORMATION
Gene name
SIRT4 (HGNC Symbol)
Synonyms
SIR2L4
Description
Sirtuin 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]