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SIRT4

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GENERAL INFORMATION

Gene name

 SIRT4

Gene description

 Sirtuin 4

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SIRT4 (HGNC Symbol)

Synonyms

 SIR2L4

Description

 Sirtuin 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 120302316 - 120313249

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089163 (version 83.38)

Entrez gene

 23409

UniProt

 Q9Y6E7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6E7

Antibodypedia

 SIRT4 antibodies

PROTEIN BROWSER
SIRT4-001
SIRT4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIRT4-001
ENSP00000202967
ENST00000202967
Q9Y6E7 [Direct mapping]
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
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   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Show all
GO:0000820 [regulation of glutamine family amino acid metabolic process]
GO:0003950 [NAD+ ADP-ribosyltransferase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006342 [chromatin silencing]
GO:0006471 [protein ADP-ribosylation]
GO:0006541 [glutamine metabolic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010667 [negative regulation of cardiac muscle cell apoptotic process]
GO:0034979 [NAD-dependent protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0046322 [negative regulation of fatty acid oxidation]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0047708 [biotinidase activity]
GO:0061690 [lipoamidase activity]
GO:0070403 [NAD+ binding]
GO:0071456 [cellular response to hypoxia]
GO:0072350 [tricarboxylic acid metabolic process]
GO:1903217 [negative regulation of protein processing involved in protein targeting to mitochondrion]
GO:1904182 [regulation of pyruvate dehydrogenase activity]
Show all
 314 aa
35.2 kDa 		No 0
SIRT4-002
ENSP00000444838
ENST00000536460
F5H4X9 [Direct mapping]
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Show all
GO:0070403 [NAD+ binding]
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 106 aa
12.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.