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Most cancer tissues exhibited moderate to strong nuclear positivity. Several cases of prostate and renal cancers were weakly stained or negative.
GENE INFORMATION
Gene name
TRMT6 (HGNC Symbol)
Synonyms
CGI-09, GCD10, Gcd10p, MGC5029
Description
TRNA methyltransferase 6 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
