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TRMT6

GENERAL INFORMATION

Gene name

 TRMT6

Gene description

 TRNA methyltransferase 6

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA047032
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRMT6 (HGNC Symbol)

Synonyms

 CGI-09, GCD10, Gcd10p, MGC5029

Description

 TRNA methyltransferase 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 20

Cytoband

 p12.3

Chromosome location (bp)

 5937235 - 5950558

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089195 (version 83.38)

Entrez gene

 51605

UniProt

 Q9UJA5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJA5

Antibodypedia

 TRMT6 antibodies

PROTEIN BROWSER
TRMT6-001
TRMT6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRMT6-001
ENSP00000203001
ENST00000203001
Q9UJA5 [Direct mapping]
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0006400 [tRNA modification]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0030488 [tRNA methylation]
GO:0031515 [tRNA (m1A) methyltransferase complex]
GO:0044822 [poly(A) RNA binding]
Show all
 497 aa
55.8 kDa 		No 0
TRMT6-201
ENSP00000392070
ENST00000453074
Q9UJA5 [Direct mapping]
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0006400 [tRNA modification]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0030488 [tRNA methylation]
GO:0031515 [tRNA (m1A) methyltransferase complex]
GO:0044822 [poly(A) RNA binding]
Show all
 327 aa
36.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.