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IGBP1

GENERAL INFORMATION

Gene name

 IGBP1

Gene description

 Immunoglobulin (CD79A) binding protein 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA000634 , HPA001004 , CAB034139
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IGBP1 (HGNC Symbol)

Synonyms

 IBP1

Description

 Immunoglobulin (CD79A) binding protein 1 (HGNC Symbol)

Entrez gene summary

 The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 70133449 - 70166324

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089289 (version 83.38)

Entrez gene

 3476

UniProt

 P78318 (UniProt - Evidence at protein level)

neXtProt

 NX_P78318

Antibodypedia

 IGBP1 antibodies

PROTEIN BROWSER
IGBP1-001
IGBP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IGBP1-001
ENSP00000363661
ENST00000342206
P78318 [Direct mapping]
Immunoglobulin-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0007165 [signal transduction]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0009966 [regulation of signal transduction]
GO:0019904 [protein domain specific binding]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0032403 [protein complex binding]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0034612 [response to tumor necrosis factor]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035308 [negative regulation of protein dephosphorylation]
GO:0042113 [B cell activation]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0051721 [protein phosphatase 2A binding]
GO:0060632 [regulation of microtubule-based movement]
GO:0070555 [response to interleukin-1]
GO:2001234 [negative regulation of apoptotic signaling pathway]
Show all
 339 aa
39.2 kDa 		No 0
IGBP1-002
ENSP00000348784
ENST00000356413
P78318 [Direct mapping]
Immunoglobulin-binding protein 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0008601 [protein phosphatase type 2A regulator activity]
GO:0009966 [regulation of signal transduction]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0034047 [regulation of protein phosphatase type 2A activity]
GO:0034612 [response to tumor necrosis factor]
GO:0042113 [B cell activation]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0051721 [protein phosphatase 2A binding]
GO:0060632 [regulation of microtubule-based movement]
GO:0070555 [response to interleukin-1]
Show all
 339 aa
39.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.