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Expression has cell cycle dependency according to biological definition
Intensity variation
Cytokinetic bridge
GENE INFORMATION
Gene name
BIRC5 (HGNC Symbol)
Synonyms
API4, EPR-1, survivin
Description
Baculoviral IAP repeat containing 5 (HGNC Symbol)
Entrez gene summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]