Expression of LAG3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Lymphocyte-activation gene 3

Protein class

CD markers, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA013967	CAB002301

GENE INFORMATION
Gene name	LAG3 (HGNC Symbol)
Synonyms	CD223
Description	Lymphocyte-activation gene 3 (HGNC Symbol)
Entrez gene summary	Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6772512 - 6778455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089692 (version 83.38)
Entrez gene	3902
UniProt	P18627 (UniProt - Evidence at protein level)
neXtProt	NX_P18627
Antibodypedia	LAG3 antibodies

PROTEIN BROWSER

LAG3-001	LAG3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAG3-001 ENSP00000203629 ENST00000203629	P18627 [Direct mapping] Lymphocyte activation gene 3 protein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003823 [antigen binding] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0042289 [MHC class II protein binding] GO:0045085 [negative regulation of interleukin-2 biosynthetic process] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050868 [negative regulation of T cell activation] Show all	525 aa 57.4 kDa	Yes	1
LAG3-003 ENSP00000413825 ENST00000441671	P18627 [Direct mapping] Lymphocyte activation gene 3 protein Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003823 [antigen binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0042289 [MHC class II protein binding] Show all	360 aa 39.1 kDa	Yes	0