Cell atlas - LAG3 - The Human Protein Atlas

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LAG3

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	LAG3
Gene description	Lymphocyte-activation gene 3
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enriched (HDLM-2)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	LAG3 (HGNC Symbol)
Synonyms	CD223
Description	Lymphocyte-activation gene 3 (HGNC Symbol)
Entrez gene summary	Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6772512 - 6778455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000089692 (version 83.38)
Entrez gene	3902
UniProt	P18627 (UniProt - Evidence at protein level)
neXtProt	NX_P18627
Antibodypedia	LAG3 antibodies

PROTEIN BROWSER

LAG3-001	LAG3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LAG3-001 ENSP00000203629 ENST00000203629	P18627 [Direct mapping] Lymphocyte activation gene 3 protein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003823 [antigen binding] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0007166 [cell surface receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0042289 [MHC class II protein binding] GO:0045085 [negative regulation of interleukin-2 biosynthetic process] GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] GO:0050868 [negative regulation of T cell activation] Show all	525 aa 57.4 kDa	Yes	1
LAG3-003 ENSP00000413825 ENST00000441671	P18627 [Direct mapping] Lymphocyte activation gene 3 protein Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003823 [antigen binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0042289 [MHC class II protein binding] Show all	360 aa 39.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.