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OTUB2

GENERAL INFORMATION

Gene name

 OTUB2

Gene description

 OTU deubiquitinase, ubiquitin aldehyde binding 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct nuclear expression in seminiferous ducts in spermatids and spermatocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA002329
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 OTUB2 (HGNC Symbol)

Synonyms

 C14orf137, FLJ21916, MGC3102

Description

 OTU deubiquitinase, ubiquitin aldehyde binding 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]

Chromosome

 14

Cytoband

 q32.12

Chromosome location (bp)

 94026329 - 94048930

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000089723 (version 83.38)

Entrez gene

 78990

UniProt

 Q96DC9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96DC9

Antibodypedia

 OTUB2 antibodies

PROTEIN BROWSER
OTUB2-001
OTUB2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OTUB2-001
ENSP00000203664
ENST00000203664
Q96DC9 [Direct mapping]
Ubiquitin thioesterase OTUB2
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0016579 [protein deubiquitination]
GO:0016787 [hydrolase activity]
GO:0019784 [NEDD8-specific protease activity]
GO:0035871 [protein K11-linked deubiquitination]
GO:0043130 [ubiquitin binding]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
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 234 aa
27.2 kDa 		No 0
OTUB2-002
ENSP00000451283
ENST00000553723
Q96DC9 [Direct mapping]
Ubiquitin thioesterase OTUB2
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0016579 [protein deubiquitination]
GO:0019784 [NEDD8-specific protease activity]
GO:0035871 [protein K11-linked deubiquitination]
GO:0043130 [ubiquitin binding]
GO:0070536 [protein K63-linked deubiquitination]
GO:0071108 [protein K48-linked deubiquitination]
Show all
 73 aa
8.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.