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Fractions of cells in cases of colorectal cancer showed distinct cytoplasmic staining. A few cases of melanomas, lung, prostate and ovarian cancers were moderately positive. Remaining cancers were weakly stained or negative.
GENE INFORMATION
Gene name
NECAP1 (HGNC Symbol)
Synonyms
DKFZP566B183
Description
NECAP endocytosis associated 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
