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MAEA

GENERAL INFORMATION

Gene name

 MAEA

Gene description

 Macrophage erythroblast attacher

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear and cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA058185
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAEA (HGNC Symbol)

Synonyms

 EMP, GID9

Description

 Macrophage erythroblast attacher (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 1289851 - 1340147

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090316 (version 83.38)

Entrez gene

 10296

UniProt

 Q7L5Y9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7L5Y9

Antibodypedia

 MAEA antibodies

PROTEIN BROWSER
MAEA-001
MAEA-002
MAEA-003
MAEA-004
MAEA-006
MAEA-007
MAEA-016
MAEA-017
MAEA-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAEA-001
ENSP00000302830
ENST00000303400
Q7L5Y9 [Direct mapping]
Macrophage erythroblast attacher
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005826 [actomyosin contractile ring]
GO:0005856 [cytoskeleton]
GO:0005887 [integral component of plasma membrane]
GO:0007010 [cytoskeleton organization]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007346 [regulation of mitotic cell cycle]
GO:0015629 [actin cytoskeleton]
GO:0016363 [nuclear matrix]
GO:0033033 [negative regulation of myeloid cell apoptotic process]
GO:0043249 [erythrocyte maturation]
GO:0048821 [erythrocyte development]
GO:0048822 [enucleate erythrocyte development]
GO:0051301 [cell division]
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 396 aa
45.3 kDa 		No 0
MAEA-002
ENSP00000422215
ENST00000505177
E7ESC7 [Direct mapping]
Macrophage erythroblast attacher
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 434 aa
49.4 kDa 		No 0
MAEA-003
ENSP00000264750
ENST00000264750
Q7L5Y9 [Direct mapping]
Macrophage erythroblast attacher
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005826 [actomyosin contractile ring]
GO:0005856 [cytoskeleton]
GO:0005887 [integral component of plasma membrane]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007346 [regulation of mitotic cell cycle]
GO:0016363 [nuclear matrix]
GO:0033033 [negative regulation of myeloid cell apoptotic process]
GO:0043249 [erythrocyte maturation]
GO:0051301 [cell division]
Show all
 355 aa
40.4 kDa 		No 0
MAEA-004
ENSP00000427512
ENST00000514708
D6RIB6 [Direct mapping]
Macrophage erythroblast attacher
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
Show all
 328 aa
36.2 kDa 		No 0
MAEA-006
ENSP00000426807
ENST00000510794
B4DVN3 [Direct mapping]
Macrophage erythroblast attacher; cDNA FLJ54556, highly similar to Homo sapiens macrophage erythroblast attacher (MAEA), transcript variant 1, mRNA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 395 aa
45.1 kDa 		No 0
MAEA-007
ENSP00000424436
ENST00000505839
B4DQT1 [Direct mapping]
Macrophage erythroblast attacher; cDNA FLJ53639, highly similar to Homo sapiens macrophage erythroblast attacher (MAEA), transcript variant 1, mRNA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 348 aa
39.8 kDa 		No 0
MAEA-016
ENSP00000427460
ENST00000512842
D6RID6 [Direct mapping]
Macrophage erythroblast attacher
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
Show all
 115 aa
12.9 kDa 		No 0
MAEA-017
ENSP00000421644
ENST00000503653
D6REW7 [Direct mapping]
Macrophage erythroblast attacher
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
Show all
 274 aa
30.4 kDa 		No 0
MAEA-018
ENSP00000426903
ENST00000502558
D6RE80 [Direct mapping]
Macrophage erythroblast attacher
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 183 aa
20.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.