We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most malignant tissues showed moderate cytoplasmic staining. Several prostate and breast cancers along with a few malignant melanoma, squamous cell carcinoma and colorectal cancers were strongly stained.
Moderate cytoplasmic immunoreactivity was observed in most cancers. Several cases of ovarian and prostate cancers were strongly stained.
GENE INFORMATION
Gene name
AARS (HGNC Symbol)
Synonyms
CMT2N
Description
Alanyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)