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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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AARS
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    CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

AARS

Gene description

Alanyl-tRNA synthetase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA040870 , CAB034261
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

AARS (HGNC Symbol)

Synonyms

CMT2N

Description

Alanyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

70252295 - 70289543

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000090861 (version 83.38)

Entrez gene

16

UniProt

P49588 (UniProt - Evidence at protein level)

neXtProt

NX_P49588

Antibodypedia

AARS antibodies

PROTEIN BROWSER

AARS-001
AARS-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AARS-001
ENSP00000261772
ENST00000261772
P49588 [Direct mapping]
Alanine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0001942 [hair follicle development]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0003676 [nucleic acid binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006400 [tRNA modification]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006419 [alanyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0006457 [protein folding]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016597 [amino acid binding]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0021680 [cerebellar Purkinje cell layer development]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034620 [cellular response to unfolded protein]
GO:0043039 [tRNA aminoacylation]
GO:0043200 [response to amino acid]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043588 [skin development]
GO:0046872 [metal ion binding]
GO:0050885 [neuromuscular process controlling balance]
GO:0050905 [neuromuscular process]
GO:0070062 [extracellular exosome]
Show all
968 aa
106.8 kDa
No 0
AARS-005
ENSP00000455360
ENST00000565361
H3BPK7 [Direct mapping]
Alanine--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006419 [alanyl-tRNA aminoacylation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
280 aa
30.1 kDa
No 0

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