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KIF4A

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GENERAL INFORMATION

Gene name

 KIF4A

Gene description

 Kinesin family member 4A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Additional location

 In addition localized to the Cytokinetic bridge (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

Cell cycle dependency

 Cell cycle dependent expression determined by biological definition

DATA RELIABILITY

Reliability score

 Validated based on 3 antibodies.
HPA034745 , HPA034746 , HPA061583
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytokinetic bridge. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Nucleoplasm (validated)

Additional location

 Cytokinetic bridge (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA034745 A-431 Nucleoplasm
HPA034745 U-2 OS Nucleoplasm
HPA034745 U-251 MG Nucleoplasm
HPA034746 A-431 Nucleoplasm
Cytokinetic bridge Intensity Intensity
HPA034746 U-2 OS Nucleoplasm
HPA034746 U-251 MG Nucleoplasm
HPA061583 RH-30 Nucleoplasm
HPA061583 SiHa Nucleoplasm
Cytokinetic bridge Intensity Intensity

CELL CYCLE

Summary

 Expression has cell cycle dependency according to biological definition

Intensity variation

 Cytokinetic bridge

GENE INFORMATION

Gene name

 KIF4A (HGNC Symbol)

Synonyms

 FLJ12530, FLJ12655, FLJ14204, FLJ20631, HSA271784, KIF4, KIF4-G1, MRX100

Description

 Kinesin family member 4A (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 70290090 - 70420832

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090889 (version 83.38)

Entrez gene

 24137

UniProt

 O95239 (UniProt - Evidence at protein level)

neXtProt

 NX_O95239

Antibodypedia

 KIF4A antibodies

PROTEIN BROWSER
KIF4A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KIF4A-001
ENSP00000363524
ENST00000374403
O95239 [Direct mapping]
Chromosome-associated kinesin KIF4A
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000281 [mitotic cytokinesis]
GO:0003677 [DNA binding]
GO:0003777 [microtubule motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005871 [kinesin complex]
GO:0005876 [spindle microtubule]
GO:0006996 [organelle organization]
GO:0007018 [microtubule-based movement]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008017 [microtubule binding]
GO:0008089 [anterograde axon cargo transport]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0016887 [ATPase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030496 [midbody]
GO:0051256 [mitotic spindle midzone assembly]
Show all
 1232 aa
139.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.