Fields »
ABOUT
HELP
BLOG
EXOC1

CANCER ATLAS

Gene description

 Exocyst complex component 1

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037706

GENE INFORMATION

Gene name

 EXOC1 (HGNC Symbol)

Synonyms

 BM-102, FLJ10893, SEC3, SEC3L1, Sec3p

Description

 Exocyst complex component 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 55853616 - 55905034

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000090989 (version 83.38)

Entrez gene

 55763

UniProt

 Q9NV70 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NV70

Antibodypedia

 EXOC1 antibodies

PROTEIN BROWSER
EXOC1-001
EXOC1-002
EXOC1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXOC1-001
ENSP00000326514
ENST00000346134
Q9NV70 [Direct mapping]
Exocyst complex component 1
A0A024RDA9 [Target identity:100%; Query identity:100%]
Exocyst complex component 1, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017049 [GTP-Rho binding]
GO:0044267 [cellular protein metabolic process]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050714 [positive regulation of protein secretion]
GO:0051601 [exocyst localization]
GO:0061024 [membrane organization]
GO:0098592 [cytoplasmic side of apical plasma membrane]
Show all
 894 aa
102 kDa 		No 0
EXOC1-002
ENSP00000334431
ENST00000349598
Q9NV70 [Direct mapping]
Exocyst complex component 1
A0A024RDA1 [Target identity:100%; Query identity:100%]
Exocyst complex component 1, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017049 [GTP-Rho binding]
GO:0044267 [cellular protein metabolic process]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050714 [positive regulation of protein secretion]
GO:0051601 [exocyst localization]
GO:0061024 [membrane organization]
GO:0098592 [cytoplasmic side of apical plasma membrane]
Show all
 879 aa
100.3 kDa 		No 0
EXOC1-003
ENSP00000370695
ENST00000381295
Q9NV70 [Direct mapping]
Exocyst complex component 1
A0A024RDA9 [Target identity:100%; Query identity:100%]
Exocyst complex component 1, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005515 [protein binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0006893 [Golgi to plasma membrane transport]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017049 [GTP-Rho binding]
GO:0044267 [cellular protein metabolic process]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050714 [positive regulation of protein secretion]
GO:0051601 [exocyst localization]
GO:0061024 [membrane organization]
GO:0098592 [cytoplasmic side of apical plasma membrane]
Show all
 894 aa
102 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.