Cell atlas - EXOC1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EXOC1
Gene description	Exocyst complex component 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol & microtubules.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Microtubules (approved), Cytosol (approved)
Mouse	Localized to the Microtubules in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044873
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol & microtubules.

Main location

Plasma membrane (approved)

Additional location

Microtubules (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA044873	A-431	Plasma membrane
HPA044873	A-431	Microtubules
HPA044873	U-2 OS	Plasma membrane
HPA044873	U-2 OS	Microtubules
HPA044873	U-251 MG	Plasma membrane
HPA044873	U-251 MG	Cytosol

MOUSE CELLS

Main location

Microtubules

Mouse gene

ENSMUSG00000036435 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA044873	NIH 3T3	Microtubules

GENE INFORMATION
Gene name	EXOC1 (HGNC Symbol)
Synonyms	BM-102, FLJ10893, SEC3, SEC3L1, Sec3p
Description	Exocyst complex component 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	55853616 - 55905034
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090989 (version 83.38)
Entrez gene	55763
UniProt	Q9NV70 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NV70
Antibodypedia	EXOC1 antibodies

PROTEIN BROWSER

EXOC1-001	EXOC1-002	EXOC1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EXOC1-001 ENSP00000326514 ENST00000346134	Q9NV70 [Direct mapping] Exocyst complex component 1 A0A024RDA9 [Target identity:100%; Query identity:100%] Exocyst complex component 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0005515 [protein binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0006893 [Golgi to plasma membrane transport] GO:0006996 [organelle organization] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017049 [GTP-Rho binding] GO:0044267 [cellular protein metabolic process] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050714 [positive regulation of protein secretion] GO:0051601 [exocyst localization] GO:0061024 [membrane organization] GO:0098592 [cytoplasmic side of apical plasma membrane] Show all	894 aa 102 kDa	No	0
EXOC1-002 ENSP00000334431 ENST00000349598	Q9NV70 [Direct mapping] Exocyst complex component 1 A0A024RDA1 [Target identity:100%; Query identity:100%] Exocyst complex component 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0005515 [protein binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0006893 [Golgi to plasma membrane transport] GO:0006996 [organelle organization] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017049 [GTP-Rho binding] GO:0044267 [cellular protein metabolic process] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050714 [positive regulation of protein secretion] GO:0051601 [exocyst localization] GO:0061024 [membrane organization] GO:0098592 [cytoplasmic side of apical plasma membrane] Show all	879 aa 100.3 kDa	No	0
EXOC1-003 ENSP00000370695 ENST00000381295	Q9NV70 [Direct mapping] Exocyst complex component 1 A0A024RDA9 [Target identity:100%; Query identity:100%] Exocyst complex component 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000145 [exocyst] GO:0005515 [protein binding] GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0006893 [Golgi to plasma membrane transport] GO:0006996 [organelle organization] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017049 [GTP-Rho binding] GO:0044267 [cellular protein metabolic process] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050714 [positive regulation of protein secretion] GO:0051601 [exocyst localization] GO:0061024 [membrane organization] GO:0098592 [cytoplasmic side of apical plasma membrane] Show all	894 aa 102 kDa	No	0