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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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RBM27
  • TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

RNA binding motif protein 27

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA035944
HPA036422

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of squamous cell carcinomas, urothelial and pancreatic cancers showed moderate to strong staining. All thyroid cancers and several cases of breast cancers and gliomas displayed moderate positivity. Remaining cancer tissues generally displayed weak nuclear staining or were negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancers showed moderate nuclear immunoreactivity. A few colorectal, breast and testicular cancers were strong stained. Strong membranous and nuclear positivity was observed in a few pancreatic cancers and cholangiocarcinomas. Gliomas, melanomas, thyroid and renal cancers along with several malignant carcinoids and hepatocellular carcinomas were negative.

GENE INFORMATION

Gene name

RBM27 (HGNC Symbol)

Synonyms

ARRS1, KIAA1311, Psc1, ZC3H20

Description

RNA binding motif protein 27 (HGNC Symbol)

Entrez gene summary

Chromosome

5

Cytoband

q32

Chromosome location (bp)

146203600 - 146289132

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091009 (version 83.38)

Entrez gene

54439

UniProt

Q9P2N5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P2N5

Antibodypedia

RBM27 antibodies

PROTEIN BROWSER

RBM27-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RBM27-001
ENSP00000265271
ENST00000265271
Q9P2N5 [Direct mapping]
RNA-binding protein 27
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
Show all
1060 aa
118.7 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.