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NLRC4

CANCER ATLAS

Gene description

 NLR family, CARD domain containing 4

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006592

GENE INFORMATION

Gene name

 NLRC4 (HGNC Symbol)

Synonyms

 CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, ipaf

Description

 NLR family, CARD domain containing 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Chromosome

 2

Cytoband

 p22.3

Chromosome location (bp)

 32224453 - 32265854

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091106 (version 83.38)

Entrez gene

 58484

UniProt

 Q9NPP4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPP4

Antibodypedia

 NLRC4 antibodies

PROTEIN BROWSER
NLRC4-001
NLRC4-002
NLRC4-003
NLRC4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLRC4-001
ENSP00000385090
ENST00000404025
Q9NPP4 [Direct mapping]
NLR family CARD domain-containing protein 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Show all
GO:0000287 [magnesium ion binding]
GO:0002218 [activation of innate immune response]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0009966 [regulation of signal transduction]
GO:0016045 [detection of bacterium]
GO:0016567 [protein ubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0050702 [interleukin-1 beta secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0070269 [pyroptosis]
GO:0072557 [IPAF inflammasome complex]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 1024 aa
116.2 kDa 		No 0
NLRC4-002
ENSP00000354159
ENST00000360906
Q9NPP4 [Direct mapping]
NLR family CARD domain-containing protein 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002218 [activation of innate immune response]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0009966 [regulation of signal transduction]
GO:0016045 [detection of bacterium]
GO:0016567 [protein ubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0050702 [interleukin-1 beta secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0070269 [pyroptosis]
GO:0072557 [IPAF inflammasome complex]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 1024 aa
116.2 kDa 		No 0
NLRC4-003
ENSP00000339666
ENST00000342905
Q9NPP4 [Direct mapping]
NLR family CARD domain-containing protein 4
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Show all
GO:0000287 [magnesium ion binding]
GO:0002218 [activation of innate immune response]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0009966 [regulation of signal transduction]
GO:0016045 [detection of bacterium]
GO:0016567 [protein ubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0050702 [interleukin-1 beta secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0070269 [pyroptosis]
GO:0072557 [IPAF inflammasome complex]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 359 aa
40.6 kDa 		No 0
NLRC4-004
ENSP00000385428
ENST00000402280
Q9NPP4 [Direct mapping]
NLR family CARD domain-containing protein 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002218 [activation of innate immune response]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0009966 [regulation of signal transduction]
GO:0016045 [detection of bacterium]
GO:0016567 [protein ubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0050702 [interleukin-1 beta secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0070269 [pyroptosis]
GO:0072557 [IPAF inflammasome complex]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 1024 aa
116.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.