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NLRC4

GENERAL INFORMATION

Gene name

 NLRC4

Gene description

 NLR family, CARD domain containing 4

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix)
GTEx:Tissue enhanced (spleen)
FANTOM5:Tissue enhanced (spleen, lymph node)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA006592
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, lymph node)

GENE INFORMATION

Gene name

 NLRC4 (HGNC Symbol)

Synonyms

 CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, ipaf

Description

 NLR family, CARD domain containing 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Chromosome

 2

Cytoband

 p22.3

Chromosome location (bp)

 32224453 - 32265854

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091106 (version 83.38)

Entrez gene

 58484

UniProt

 Q9NPP4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPP4

Antibodypedia

 NLRC4 antibodies

PROTEIN BROWSER
NLRC4-001
NLRC4-002
NLRC4-003
NLRC4-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLRC4-001
ENSP00000385090
ENST00000404025
Q9NPP4 [Direct mapping]
NLR family CARD domain-containing protein 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Show all
GO:0000287 [magnesium ion binding]
GO:0002218 [activation of innate immune response]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0009966 [regulation of signal transduction]
GO:0016045 [detection of bacterium]
GO:0016567 [protein ubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0050702 [interleukin-1 beta secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0070269 [pyroptosis]
GO:0072557 [IPAF inflammasome complex]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 1024 aa
116.2 kDa 		No 0
NLRC4-002
ENSP00000354159
ENST00000360906
Q9NPP4 [Direct mapping]
NLR family CARD domain-containing protein 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002218 [activation of innate immune response]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0009966 [regulation of signal transduction]
GO:0016045 [detection of bacterium]
GO:0016567 [protein ubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0050702 [interleukin-1 beta secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0070269 [pyroptosis]
GO:0072557 [IPAF inflammasome complex]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 1024 aa
116.2 kDa 		No 0
NLRC4-003
ENSP00000339666
ENST00000342905
Q9NPP4 [Direct mapping]
NLR family CARD domain-containing protein 4
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Show all
GO:0000287 [magnesium ion binding]
GO:0002218 [activation of innate immune response]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0009966 [regulation of signal transduction]
GO:0016045 [detection of bacterium]
GO:0016567 [protein ubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0050702 [interleukin-1 beta secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0070269 [pyroptosis]
GO:0072557 [IPAF inflammasome complex]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 359 aa
40.6 kDa 		No 0
NLRC4-004
ENSP00000385428
ENST00000402280
Q9NPP4 [Direct mapping]
NLR family CARD domain-containing protein 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002218 [activation of innate immune response]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005876 [spindle microtubule]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0009966 [regulation of signal transduction]
GO:0016045 [detection of bacterium]
GO:0016567 [protein ubiquitination]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043523 [regulation of neuron apoptotic process]
GO:0045087 [innate immune response]
GO:0050702 [interleukin-1 beta secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051260 [protein homooligomerization]
GO:0070269 [pyroptosis]
GO:0072557 [IPAF inflammasome complex]
GO:0090307 [mitotic spindle assembly]
GO:1990001 [inhibition of cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 1024 aa
116.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.