Expression of SLC26A4 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 26 (anion exchanger), member 4

Protein class

Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042860

GENE INFORMATION
Gene name	SLC26A4 (HGNC Symbol)
Synonyms	DFNB4, PDS
Description	Solute carrier family 26 (anion exchanger), member 4 (HGNC Symbol)
Entrez gene summary	Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.3
Chromosome location (bp)	107660635 - 107717809
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091137 (version 83.38)
Entrez gene	5172
UniProt	O43511 (UniProt - Evidence at protein level)
neXtProt	NX_O43511
Antibodypedia	SLC26A4 antibodies

PROTEIN BROWSER

SLC26A4-001	SLC26A4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC26A4-001 ENSP00000265715 ENST00000265715	O43511 [Direct mapping] Pendrin Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006885 [regulation of pH] GO:0007605 [sensory perception of sound] GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0008272 [sulfate transport] GO:0015106 [bicarbonate transmembrane transporter activity] GO:0015108 [chloride transmembrane transporter activity] GO:0015111 [iodide transmembrane transporter activity] GO:0015116 [sulfate transmembrane transporter activity] GO:0015301 [anion:anion antiporter activity] GO:0015698 [inorganic anion transport] GO:0015701 [bicarbonate transport] GO:0015705 [iodide transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0019531 [oxalate transmembrane transporter activity] GO:0019532 [oxalate transport] GO:0031526 [brush border membrane] GO:0032880 [regulation of protein localization] GO:0042391 [regulation of membrane potential] GO:0051453 [regulation of intracellular pH] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1902358 [sulfate transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	780 aa 85.7 kDa	No	>9
SLC26A4-002 ENSP00000394760 ENST00000440056	C9JQG1 [Direct mapping] Pendrin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0008271 [secondary active sulfate transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:1902358 [sulfate transmembrane transport] Show all	131 aa 14.7 kDa	No	2