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TXNL1

GENERAL INFORMATION

Gene name

 TXNL1

Gene description

 Thioredoxin-like 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in all tissues at variable levels, highest expression in the thyroid gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA002828 , HPA002829 , CAB016446
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TXNL1 (HGNC Symbol)

Synonyms

 TRP32, Txl, TXNL

Description

 Thioredoxin-like 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 18

Cytoband

 q21.31

Chromosome location (bp)

 56597208 - 56651600

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091164 (version 83.38)

Entrez gene

 9352

UniProt

 O43396 (UniProt - Evidence at protein level)

neXtProt

 NX_O43396

Antibodypedia

 TXNL1 antibodies

PROTEIN BROWSER
TXNL1-001
TXNL1-002
TXNL1-004
TXNL1-005
TXNL1-006
TXNL1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TXNL1-001
ENSP00000217515
ENST00000217515
O43396 [Direct mapping]
Thioredoxin-like protein 1
V9HW51 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 114; Thioredoxin-like 1, isoform CRA_c
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0000502 [proteasome complex]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
GO:0006662 [glycerol ether metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0034599 [cellular response to oxidative stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 289 aa
32.3 kDa 		No 0
TXNL1-002
ENSP00000464918
ENST00000590954
O43396 [Direct mapping]
Thioredoxin-like protein 1
V9HW51 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 114; Thioredoxin-like 1, isoform CRA_c
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0000502 [proteasome complex]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
GO:0006662 [glycerol ether metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0015036 [disulfide oxidoreductase activity]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0034599 [cellular response to oxidative stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 289 aa
32.3 kDa 		No 0
TXNL1-004
ENSP00000468165
ENST00000586262
K7ER96 [Direct mapping]
Thioredoxin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0005623 [cell]
GO:0006457 [protein folding]
GO:0006662 [glycerol ether metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0034599 [cellular response to oxidative stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 281 aa
31.4 kDa 		No 0
TXNL1-005
ENSP00000465606
ENST00000589329
K7EKG2 [Direct mapping]
Thioredoxin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0005623 [cell]
GO:0006457 [protein folding]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0034599 [cellular response to oxidative stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 27 aa
2.7 kDa 		No 0
TXNL1-006
ENSP00000466558
ENST00000587613
K7EML9 [Direct mapping]
Thioredoxin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0005623 [cell]
GO:0006457 [protein folding]
GO:0006662 [glycerol ether metabolic process]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0034599 [cellular response to oxidative stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 138 aa
15.5 kDa 		No 0
TXNL1-008
ENSP00000466473
ENST00000589931
K7EME7 [Direct mapping]
Thioredoxin-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0005623 [cell]
GO:0006457 [protein folding]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor]
GO:0034599 [cellular response to oxidative stress]
GO:0045454 [cell redox homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 103 aa
12 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.