Expression of CMA1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Chymase 1, mast cell

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA052634	CAB000363

GENE INFORMATION
Gene name	CMA1
Synonyms
Description	Chymase 1, mast cell (HGNC Symbol)
Entrez gene summary	This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24505353 - 24508265
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000092009 (version 83.38)
Entrez gene	1215
UniProt	P23946 (UniProt - Evidence at protein level)
neXtProt	NX_P23946
Antibodypedia	CMA1 antibodies

PROTEIN BROWSER

CMA1-001	CMA1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CMA1-001 ENSP00000250378 ENST00000250378	P23946 [Direct mapping] Chymase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002003 [angiotensin maturation] GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0006508 [proteolysis] GO:0006518 [peptide metabolic process] GO:0008236 [serine-type peptidase activity] GO:0016485 [protein processing] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030901 [midbrain development] GO:0031012 [extracellular matrix] GO:0042277 [peptide binding] GO:0044267 [cellular protein metabolic process] GO:0045766 [positive regulation of angiogenesis] GO:0050720 [interleukin-1 beta biosynthetic process] GO:0050727 [regulation of inflammatory response] GO:0071333 [cellular response to glucose stimulus] Show all	247 aa 27.3 kDa	Yes	0
CMA1-002 ENSP00000206446 ENST00000206446	P23946 [Direct mapping] Chymase Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002003 [angiotensin maturation] GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016485 [protein processing] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0044267 [cellular protein metabolic process] GO:0050720 [interleukin-1 beta biosynthetic process] GO:0050727 [regulation of inflammatory response] Show all	136 aa 14.9 kDa	No	0