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CMA1

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GENERAL INFORMATION

Gene name

 CMA1

Gene description

 Chymase 1, mast cell

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CMA1

Synonyms

Description

 Chymase 1, mast cell (HGNC Symbol)

Entrez gene summary

 This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]

Chromosome

 14

Cytoband

 q12

Chromosome location (bp)

 24505353 - 24508265

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092009 (version 83.38)

Entrez gene

 1215

UniProt

 P23946 (UniProt - Evidence at protein level)

neXtProt

 NX_P23946

Antibodypedia

 CMA1 antibodies

PROTEIN BROWSER
CMA1-001
CMA1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CMA1-001
ENSP00000250378
ENST00000250378
P23946 [Direct mapping]
Chymase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002003 [angiotensin maturation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
GO:0006518 [peptide metabolic process]
GO:0008236 [serine-type peptidase activity]
GO:0016485 [protein processing]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030901 [midbrain development]
GO:0031012 [extracellular matrix]
GO:0042277 [peptide binding]
GO:0044267 [cellular protein metabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0050720 [interleukin-1 beta biosynthetic process]
GO:0050727 [regulation of inflammatory response]
GO:0071333 [cellular response to glucose stimulus]
Show all
 247 aa
27.3 kDa 		Yes 0
CMA1-002
ENSP00000206446
ENST00000206446
P23946 [Direct mapping]
Chymase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002003 [angiotensin maturation]
GO:0004252 [serine-type endopeptidase activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0008236 [serine-type peptidase activity]
GO:0016485 [protein processing]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0044267 [cellular protein metabolic process]
GO:0050720 [interleukin-1 beta biosynthetic process]
GO:0050727 [regulation of inflammatory response]
Show all
 136 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.