Cell atlas - TBX15 - The Human Protein Atlas

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TBX15

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TBX15
Gene description	T-box 15
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the centrosome.
RNA cell category	Cell line enhanced (RH-30, U-2197, BJ hTERT+ SV40 Large T+ RasG12V, ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA053713
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30, U-2197, BJ hTERT+ SV40 Large T+ RasG12V, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the centrosome.

Main location

Nucleoplasm (approved)

Additional location

Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053713	RH-30	Nucleoplasm
	HPA053713	RH-30	Centrosome
	HPA053713	U-2 OS	No staining

GENE INFORMATION
Gene name	TBX15 (HGNC Symbol)
Synonyms	TBX14
Description	T-box 15 (HGNC Symbol)
Entrez gene summary	This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	p12
Chromosome location (bp)	118883046 - 118989556
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000092607 (version 83.38)
Entrez gene	6913
UniProt	Q96SF7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96SF7
Antibodypedia	TBX15 antibodies

PROTEIN BROWSER

TBX15-001	TBX15-002	TBX15-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBX15-001 ENSP00000207157 ENST00000207157	Q96SF7 [Direct mapping] T-box transcription factor TBX15 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001106 [RNA polymerase II transcription corepressor activity] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0048704 [embryonic skeletal system morphogenesis] GO:0070722 [Tle3-Aes complex] Show all	496 aa 54.7 kDa	No	0
TBX15-002 ENSP00000358437 ENST00000369429	Q96SF7 [Direct mapping] T-box transcription factor TBX15 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	602 aa 65.8 kDa	No	0
TBX15-003 ENSP00000398625 ENST00000449873	Q5JT55 [Direct mapping] T-box transcription factor TBX15 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	330 aa 35.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.