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TBX15

GENERAL INFORMATION

Gene name

 TBX15

Gene description

 T-box 15

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (skeletal muscle, liver, adipose tissue, breast)
GTEx:Tissue enhanced (skeletal muscle)
FANTOM5:Group enriched (skeletal muscle, adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in skeletal myocytes and a subset of neuronal cells in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA052245
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, liver, adipose tissue, breast)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, adipose tissue)

GENE INFORMATION

Gene name

 TBX15 (HGNC Symbol)

Synonyms

 TBX14

Description

 T-box 15 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.[provided by RefSeq, Oct 2009]

Chromosome

 1

Cytoband

 p12

Chromosome location (bp)

 118883046 - 118989556

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092607 (version 83.38)

Entrez gene

 6913

UniProt

 Q96SF7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96SF7

Antibodypedia

 TBX15 antibodies

PROTEIN BROWSER
TBX15-001
TBX15-002
TBX15-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TBX15-001
ENSP00000207157
ENST00000207157
Q96SF7 [Direct mapping]
T-box transcription factor TBX15
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0042803 [protein homodimerization activity]
GO:0046982 [protein heterodimerization activity]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0048704 [embryonic skeletal system morphogenesis]
GO:0070722 [Tle3-Aes complex]
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 496 aa
54.7 kDa 		No 0
TBX15-002
ENSP00000358437
ENST00000369429
Q96SF7 [Direct mapping]
T-box transcription factor TBX15
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
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 602 aa
65.8 kDa 		No 0
TBX15-003
ENSP00000398625
ENST00000449873
Q5JT55 [Direct mapping]
T-box transcription factor TBX15
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Predicted intracellular proteins
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
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 330 aa
35.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.