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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

COMT

Gene description

Catechol-O-methyltransferase

Protein class

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression at variable levels in all tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression profile.

Reliability score

Supported based on 2 antibodies.
HPA001169 , CAB011233
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin050100150200TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520253035RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0100200300400Tags Per Million

GENE INFORMATION

Gene name

COMT

Synonyms

Description

Catechol-O-methyltransferase (HGNC Symbol)

Entrez gene summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

19941607 - 19969975

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000093010 (version 83.38)

Entrez gene

1312

UniProt

P21964 (UniProt - Evidence at protein level)

neXtProt

NX_P21964

Antibodypedia

COMT antibodies

PROTEIN BROWSER

COMT-001
COMT-002
COMT-003
COMT-004
COMT-005
COMT-008
COMT-011
COMT-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COMT-001
ENSP00000385150
ENST00000406520
P21964 [Direct mapping]
Catechol O-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006584 [catecholamine metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007268 [synaptic transmission]
GO:0008171 [O-methyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016206 [catechol O-methyltransferase activity]
GO:0032259 [methylation]
GO:0042135 [neurotransmitter catabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
271 aa
30 kDa
No 0
COMT-002
ENSP00000385917
ENST00000403710
P21964 [Direct mapping]
Catechol O-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006584 [catecholamine metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007268 [synaptic transmission]
GO:0008171 [O-methyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016206 [catechol O-methyltransferase activity]
GO:0032259 [methylation]
GO:0042135 [neurotransmitter catabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
271 aa
30 kDa
No 0
COMT-003
ENSP00000384654
ENST00000407537
P21964 [Direct mapping]
Catechol O-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006584 [catecholamine metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007268 [synaptic transmission]
GO:0008171 [O-methyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016206 [catechol O-methyltransferase activity]
GO:0032259 [methylation]
GO:0042135 [neurotransmitter catabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
271 aa
30 kDa
No 0
COMT-004
ENSP00000383966
ENST00000403184
E7EUU8 [Direct mapping]
Catechol O-methyltransferase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0006584 [catecholamine metabolic process]
GO:0008171 [O-methyltransferase activity]
GO:0016206 [catechol O-methyltransferase activity]
GO:0032259 [methylation]
GO:0042135 [neurotransmitter catabolic process]
Show all
235 aa
26 kDa
No 0
COMT-005
ENSP00000403958
ENST00000412786
E7EMS6 [Direct mapping]
Catechol O-methyltransferase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0006584 [catecholamine metabolic process]
GO:0008171 [O-methyltransferase activity]
GO:0016206 [catechol O-methyltransferase activity]
GO:0032259 [methylation]
GO:0042135 [neurotransmitter catabolic process]
Show all
223 aa
24.8 kDa
No 0
COMT-008
ENSP00000387695
ENST00000428707
H7BZ45 [Direct mapping]
Catechol O-methyltransferase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008171 [O-methyltransferase activity]
GO:0032259 [methylation]
Show all
152 aa
16.8 kDa
No 1
COMT-011
ENSP00000354511
ENST00000361682
P21964 [Direct mapping]
Catechol O-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006584 [catecholamine metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007268 [synaptic transmission]
GO:0007565 [female pregnancy]
GO:0007612 [learning]
GO:0007614 [short-term memory]
GO:0008171 [O-methyltransferase activity]
GO:0008210 [estrogen metabolic process]
GO:0009712 [catechol-containing compound metabolic process]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016036 [cellular response to phosphate starvation]
GO:0016206 [catechol O-methyltransferase activity]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032259 [methylation]
GO:0032496 [response to lipopolysaccharide]
GO:0032502 [developmental process]
GO:0035814 [negative regulation of renal sodium excretion]
GO:0042135 [neurotransmitter catabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0042417 [dopamine metabolic process]
GO:0042420 [dopamine catabolic process]
GO:0042493 [response to drug]
GO:0043197 [dendritic spine]
GO:0044281 [small molecule metabolic process]
GO:0044297 [cell body]
GO:0045211 [postsynaptic membrane]
GO:0045963 [negative regulation of dopamine metabolic process]
GO:0048265 [response to pain]
GO:0048609 [multicellular organismal reproductive process]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050668 [positive regulation of homocysteine metabolic process]
GO:0051930 [regulation of sensory perception of pain]
GO:0070062 [extracellular exosome]
Show all
271 aa
30 kDa
No 0
COMT-012
ENSP00000416778
ENST00000449653
P21964 [Direct mapping]
Catechol O-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006584 [catecholamine metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007268 [synaptic transmission]
GO:0008171 [O-methyltransferase activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016206 [catechol O-methyltransferase activity]
GO:0032259 [methylation]
GO:0042135 [neurotransmitter catabolic process]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
221 aa
24.4 kDa
No 0

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