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CBX5

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GENERAL INFORMATION

Gene name

 CBX5

Gene description

 Chromobox homolog 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA016699 , CAB017548
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus.

Main location

 Nucleus (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA016699 U-2 OS Nucleus
HPA016699 U-251 MG Nucleoplasm
CAB017548 A-431 Nucleoplasm
CAB017548 U-2 OS Nucleoplasm
CAB017548 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 CBX5 (HGNC Symbol)

Synonyms

 HP1, HP1-ALPHA, HP1Hs-alpha

Description

 Chromobox homolog 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 54230940 - 54280133

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000094916 (version 83.38)

Entrez gene

 23468

UniProt

 P45973 (UniProt - Evidence at protein level)

neXtProt

 NX_P45973

Antibodypedia

 CBX5 antibodies

PROTEIN BROWSER
CBX5-002
CBX5-003
CBX5-004
CBX5-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBX5-002
ENSP00000209875
ENST00000209875
P45973 [Direct mapping]
Chromobox protein homolog 5
V9HWG0 [Target identity:100%; Query identity:100%]
Chromobox homolog 5 (HP1 alpha homolog, Drosophila), isoform CRA_b; Epididymis luminal protein 25
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000776 [kinetochore]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000792 [heterochromatin]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005730 [nucleolus]
GO:0007596 [blood coagulation]
GO:0010369 [chromocenter]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0017053 [transcriptional repressor complex]
GO:0030674 [protein binding, bridging]
GO:0031618 [nuclear pericentric heterochromatin]
GO:0035064 [methylated histone binding]
GO:0035097 [histone methyltransferase complex]
GO:0042803 [protein homodimerization activity]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070491 [repressing transcription factor binding]
Show all
 191 aa
22.2 kDa 		No 0
CBX5-003
ENSP00000449207
ENST00000550411
P45973 [Direct mapping]
Chromobox protein homolog 5
V9HWG0 [Target identity:100%; Query identity:100%]
Chromobox homolog 5 (HP1 alpha homolog, Drosophila), isoform CRA_b; Epididymis luminal protein 25
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005730 [nucleolus]
GO:0007596 [blood coagulation]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0017053 [transcriptional repressor complex]
GO:0030674 [protein binding, bridging]
GO:0031618 [nuclear pericentric heterochromatin]
GO:0035064 [methylated histone binding]
GO:0035097 [histone methyltransferase complex]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070491 [repressing transcription factor binding]
Show all
 191 aa
22.2 kDa 		No 0
CBX5-004
ENSP00000401009
ENST00000439541
P45973 [Direct mapping]
Chromobox protein homolog 5
V9HWG0 [Target identity:100%; Query identity:100%]
Chromobox homolog 5 (HP1 alpha homolog, Drosophila), isoform CRA_b; Epididymis luminal protein 25
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005720 [nuclear heterochromatin]
GO:0005730 [nucleolus]
GO:0007596 [blood coagulation]
GO:0016032 [viral process]
GO:0016605 [PML body]
GO:0017053 [transcriptional repressor complex]
GO:0030674 [protein binding, bridging]
GO:0031618 [nuclear pericentric heterochromatin]
GO:0035064 [methylated histone binding]
GO:0035097 [histone methyltransferase complex]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070491 [repressing transcription factor binding]
Show all
 191 aa
22.2 kDa 		No 0
CBX5-005
ENSP00000450190
ENST00000552562
F8VNY3 [Direct mapping]
Chromobox protein homolog 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
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 91 aa
10.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.