Expression of DDT in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

D-dopachrome tautomerase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA049871

GENE INFORMATION
Gene name	DDT (HGNC Symbol)
Synonyms	DDCT
Description	D-dopachrome tautomerase (HGNC Symbol)
Entrez gene summary	D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	23971365 - 23980469
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099977 (version 83.38)
Entrez gene	1652
UniProt	P30046 (UniProt - Evidence at protein level)
neXtProt	NX_P30046
Antibodypedia	DDT antibodies

PROTEIN BROWSER

DDT-001	DDT-002	DDT-003	DDT-005	DDT-006	DDT-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDT-001 ENSP00000215773 ENST00000350608	P30046 [Direct mapping] D-dopachrome decarboxylase Q53Y51 [Target identity:100%; Query identity:100%] D-dopachrome tautomerase; D-dopachrome tautomerase 1; D-dopachrome tautomerase, isoform CRA_b; cDNA FLJ76419, highly similar to Homo sapiens D-dopachrome tautomerase (DDT), mRNA Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004167 [dopachrome isomerase activity] GO:0005737 [cytoplasm] GO:0033981 [D-dopachrome decarboxylase activity] GO:0042438 [melanin biosynthetic process] GO:0070062 [extracellular exosome] Show all	118 aa 12.7 kDa	No	0
DDT-002 ENSP00000381386 ENST00000398344	P30046 [Direct mapping] D-dopachrome decarboxylase Q53Y51 [Target identity:100%; Query identity:100%] D-dopachrome tautomerase; D-dopachrome tautomerase 1; D-dopachrome tautomerase, isoform CRA_b; cDNA FLJ76419, highly similar to Homo sapiens D-dopachrome tautomerase (DDT), mRNA Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004167 [dopachrome isomerase activity] GO:0005737 [cytoplasm] GO:0033981 [D-dopachrome decarboxylase activity] GO:0042438 [melanin biosynthetic process] GO:0070062 [extracellular exosome] Show all	118 aa 12.7 kDa	No	0
DDT-003 ENSP00000385714 ENST00000404092	J3KQ18 [Direct mapping] D-dopachrome decarboxylase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.2 kDa	Yes	0
DDT-005 ENSP00000384866 ENST00000403754	B5MC82 [Direct mapping] D-dopachrome decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		166 aa 17.7 kDa	No	0
DDT-006 ENSP00000399768 ENST00000430101	P30046 [Direct mapping] D-dopachrome decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004167 [dopachrome isomerase activity] GO:0005737 [cytoplasm] GO:0033981 [D-dopachrome decarboxylase activity] GO:0042438 [melanin biosynthetic process] GO:0070062 [extracellular exosome] Show all	107 aa 11.3 kDa	No	0
DDT-007 ENSP00000409440 ENST00000428792	H7C342 [Direct mapping] D-dopachrome decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.6 kDa	No	0