Tissue expression of DDT - Summary - The Human Protein Atlas

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DDT

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DDT
Gene description	D-dopachrome tautomerase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA049871
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DDT (HGNC Symbol)
Synonyms	DDCT
Description	D-dopachrome tautomerase (HGNC Symbol)
Entrez gene summary	D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	23971365 - 23980469
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099977 (version 83.38)
Entrez gene	1652
UniProt	P30046 (UniProt - Evidence at protein level)
neXtProt	NX_P30046
Antibodypedia	DDT antibodies

PROTEIN BROWSER

DDT-001	DDT-002	DDT-003	DDT-005	DDT-006	DDT-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDT-001 ENSP00000215773 ENST00000350608	P30046 [Direct mapping] D-dopachrome decarboxylase Q53Y51 [Target identity:100%; Query identity:100%] D-dopachrome tautomerase; D-dopachrome tautomerase 1; D-dopachrome tautomerase, isoform CRA_b; cDNA FLJ76419, highly similar to Homo sapiens D-dopachrome tautomerase (DDT), mRNA Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004167 [dopachrome isomerase activity] GO:0005737 [cytoplasm] GO:0033981 [D-dopachrome decarboxylase activity] GO:0042438 [melanin biosynthetic process] GO:0070062 [extracellular exosome] Show all	118 aa 12.7 kDa	No	0
DDT-002 ENSP00000381386 ENST00000398344	P30046 [Direct mapping] D-dopachrome decarboxylase Q53Y51 [Target identity:100%; Query identity:100%] D-dopachrome tautomerase; D-dopachrome tautomerase 1; D-dopachrome tautomerase, isoform CRA_b; cDNA FLJ76419, highly similar to Homo sapiens D-dopachrome tautomerase (DDT), mRNA Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004167 [dopachrome isomerase activity] GO:0005737 [cytoplasm] GO:0033981 [D-dopachrome decarboxylase activity] GO:0042438 [melanin biosynthetic process] GO:0070062 [extracellular exosome] Show all	118 aa 12.7 kDa	No	0
DDT-003 ENSP00000385714 ENST00000404092	J3KQ18 [Direct mapping] D-dopachrome decarboxylase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		132 aa 14.2 kDa	Yes	0
DDT-005 ENSP00000384866 ENST00000403754	B5MC82 [Direct mapping] D-dopachrome decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		166 aa 17.7 kDa	No	0
DDT-006 ENSP00000399768 ENST00000430101	P30046 [Direct mapping] D-dopachrome decarboxylase Show all	Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004167 [dopachrome isomerase activity] GO:0005737 [cytoplasm] GO:0033981 [D-dopachrome decarboxylase activity] GO:0042438 [melanin biosynthetic process] GO:0070062 [extracellular exosome] Show all	107 aa 11.3 kDa	No	0
DDT-007 ENSP00000409440 ENST00000428792	H7C342 [Direct mapping] D-dopachrome decarboxylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.