Expression of GGT1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Gamma-glutamyltransferase 1

Protein class

Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA045635	HPA047534

GENE INFORMATION
Gene name	GGT1 (HGNC Symbol)
Synonyms	CD224, D22S672, D22S732, GGT
Description	Gamma-glutamyltransferase 1 (HGNC Symbol)
Entrez gene summary	The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	24583750 - 24629005
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100031 (version 83.38)
Entrez gene	2678
UniProt	P19440 (UniProt - Evidence at protein level)
neXtProt	NX_P19440
Antibodypedia	GGT1 antibodies

PROTEIN BROWSER

GGT1-001	GGT1-002	GGT1-003	GGT1-004	GGT1-005	GGT1-010	GGT1-011	GGT1-012	GGT1-013	GGT1-014	GGT1-015	GGT1-016	GGT1-017	GGT1-018	GGT1-019	GGT1-020	GGT1-023	GGT1-024	GGT1-025	GGT1-026	GGT1-027	GGT1-028

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GGT1-001 ENSP00000383231 ENST00000400380	P19440 [Direct mapping] Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 heavy chain Gamma-glutamyltranspeptidase 1 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0002682 [regulation of immune system process] GO:0003840 [gamma-glutamyltransferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006536 [glutamate metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006751 [glutathione catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007283 [spermatogenesis] GO:0016021 [integral component of membrane] GO:0019344 [cysteine biosynthetic process] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0031638 [zymogen activation] GO:0036374 [glutathione hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0050727 [regulation of inflammatory response] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	569 aa 61.4 kDa	Yes	1
GGT1-002 ENSP00000383232 ENST00000400382	P19440 [Direct mapping] Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 heavy chain Gamma-glutamyltranspeptidase 1 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0002682 [regulation of immune system process] GO:0003840 [gamma-glutamyltransferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006536 [glutamate metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006751 [glutathione catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007283 [spermatogenesis] GO:0016021 [integral component of membrane] GO:0019344 [cysteine biosynthetic process] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0031638 [zymogen activation] GO:0036374 [glutathione hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0050727 [regulation of inflammatory response] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	569 aa 61.4 kDa	Yes	1
GGT1-003 ENSP00000393537 ENST00000412658	E7ET76 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	463 aa 50.1 kDa	Yes	1
GGT1-004 ENSP00000415553 ENST00000452551	E7ETJ6 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	127 aa 13.4 kDa	Yes	1
GGT1-005 ENSP00000248923 ENST00000248923	P19440 [Direct mapping] Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 heavy chain Gamma-glutamyltranspeptidase 1 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002682 [regulation of immune system process] GO:0003840 [gamma-glutamyltransferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006536 [glutamate metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006751 [glutathione catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007283 [spermatogenesis] GO:0016021 [integral component of membrane] GO:0019344 [cysteine biosynthetic process] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0031638 [zymogen activation] GO:0036374 [glutathione hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0050727 [regulation of inflammatory response] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	569 aa 61.4 kDa	Yes	1
GGT1-010 ENSP00000415129 ENST00000456869	C9JGF3 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	30 aa 3.2 kDa	No	0
GGT1-011 ENSP00000389935 ENST00000411974	E7ENJ5 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	120 aa 12.6 kDa	Yes	1
GGT1-012 ENSP00000393135 ENST00000445029	E9PHP2 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	68 aa 7.1 kDa	Yes	0
GGT1-013 ENSP00000395271 ENST00000419133	E7ETR7 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	174 aa 18.5 kDa	Yes	1
GGT1-014 ENSP00000408151 ENST00000412898	E7ERN9 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	80 aa 8.3 kDa	Yes	0
GGT1-015 ENSP00000415024 ENST00000455483	E7ETN1 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	98 aa 10.1 kDa	Yes	1
GGT1-016 ENSP00000400621 ENST00000447416	E7EM62 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	126 aa 13.2 kDa	Yes	1
GGT1-017 ENSP00000398589 ENST00000432867	E7ETU4 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	111 aa 11.5 kDa	Yes	1
GGT1-018 ENSP00000387796 ENST00000451366	E7EVF8 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	116 aa 12.1 kDa	Yes	1
GGT1-019 ENSP00000403826 ENST00000438643	C9JIY6 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	37 aa 4 kDa	Yes	0
GGT1-020 ENSP00000415068 ENST00000428855	E7EM62 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	126 aa 13.2 kDa	Yes	1
GGT1-023 ENSP00000417044 ENST00000430289	E7ESL5 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	109 aa 11.4 kDa	Yes	1
GGT1-024 ENSP00000384820 ENST00000403838	P19440 [Direct mapping] Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 heavy chain Gamma-glutamyltranspeptidase 1 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases CD markers Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0002682 [regulation of immune system process] GO:0003840 [gamma-glutamyltransferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006536 [glutamate metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006751 [glutathione catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007283 [spermatogenesis] GO:0016021 [integral component of membrane] GO:0019344 [cysteine biosynthetic process] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0031638 [zymogen activation] GO:0036374 [glutathione hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0050727 [regulation of inflammatory response] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	225 aa 24.1 kDa	No	0
GGT1-025 ENSP00000384381 ENST00000401885	P19440 [Direct mapping] Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 heavy chain Gamma-glutamyltranspeptidase 1 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases CD markers Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0002682 [regulation of immune system process] GO:0003840 [gamma-glutamyltransferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006536 [glutamate metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006751 [glutathione catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007283 [spermatogenesis] GO:0016021 [integral component of membrane] GO:0019344 [cysteine biosynthetic process] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0031638 [zymogen activation] GO:0036374 [glutathione hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0050727 [regulation of inflammatory response] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	225 aa 24.1 kDa	No	0
GGT1-026 ENSP00000385445 ENST00000404532	P19440 [Direct mapping] Gamma-glutamyltranspeptidase 1 Gamma-glutamyltranspeptidase 1 heavy chain Gamma-glutamyltranspeptidase 1 light chain Show all	Enzymes ENZYME proteins Transferases Hydrolases CD markers Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0002682 [regulation of immune system process] GO:0003840 [gamma-glutamyltransferase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006536 [glutamate metabolic process] GO:0006691 [leukotriene metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006751 [glutathione catabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007283 [spermatogenesis] GO:0016021 [integral component of membrane] GO:0019344 [cysteine biosynthetic process] GO:0019369 [arachidonic acid metabolic process] GO:0019370 [leukotriene biosynthetic process] GO:0031362 [anchored component of external side of plasma membrane] GO:0031638 [zymogen activation] GO:0036374 [glutathione hydrolase activity] GO:0044281 [small molecule metabolic process] GO:0050727 [regulation of inflammatory response] GO:0070062 [extracellular exosome] GO:1901687 [glutathione derivative biosynthetic process] Show all	225 aa 24.1 kDa	No	0
GGT1-027 ENSP00000385001 ENST00000404920	B5MC36 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	218 aa 23.6 kDa	No	0
GGT1-028 ENSP00000385016 ENST00000404223	B5MC34 [Direct mapping] Gamma-glutamyltranspeptidase 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003840 [gamma-glutamyltransferase activity] GO:0006749 [glutathione metabolic process] Show all	252 aa 27 kDa	No	0