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The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
Enzymes ENZYME proteins Transferases Hydrolases CD markers Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Hydrolases CD markers Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Hydrolases CD markers Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)