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Cancer tissues displayed moderate to strong nuclear/nucleolar staining. Several cases of gliomas, lung and ovarian cancers were weakly stained or negative.
Cancer tissues displayed moderate to strong nuclear positivity.
GENE INFORMATION
Gene name
HIRA (HGNC Symbol)
Synonyms
DGCR1, TUP1, TUPLE1
Description
Histone cell cycle regulator (HGNC Symbol)
Entrez gene summary
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]