Cell atlas - SEPT3 - The Human Protein Atlas

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SEPT3

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Nucleoplasm
	Plasma membrane

Human cell
	Actin Filaments
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SEPT3
Gene description	Septin 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the actin filaments.
RNA cell category	Cell line enhanced (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Plasma membrane (approved)
Additional location	In addition localized to the Actin filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003548
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & nucleoplasm. In addition localized to the actin filaments.

Main location

Nucleoplasm (approved), Plasma membrane (approved)

Additional location

Actin filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003548	A-431	Nucleoplasm
	HPA003548	A-431	Plasma membrane
	HPA003548	U-2 OS	Nucleoplasm
			Plasma membrane
			Actin filaments
	HPA003548	U-251 MG	Nucleoplasm
	HPA003548	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	SEPT3 (HGNC Symbol)
Synonyms	SEP3
Description	Septin 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	41976272 - 41998221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100167 (version 83.38)
Entrez gene	55964
UniProt	Q9UH03 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UH03
Antibodypedia	SEPT3 antibodies

PROTEIN BROWSER

SEPT3-001	SEPT3-003	SEPT3-004	SEPT3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEPT3-001 ENSP00000379703 ENST00000396425	Q9UH03 [Direct mapping] Neuronal-specific septin-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0007049 [cell cycle] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0051301 [cell division] Show all	350 aa 40.1 kDa	No	0
SEPT3-003 ENSP00000379704 ENST00000396426	Q9UH03 [Direct mapping] Neuronal-specific septin-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0007049 [cell cycle] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0051301 [cell division] Show all	358 aa 40.7 kDa	No	0
SEPT3-004 ENSP00000383956 ENST00000406029	B1AHR1 [Direct mapping] Neuronal-specific septin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0007049 [cell cycle] Show all	294 aa 33.6 kDa	No	0
SEPT3-006 ENSP00000391416 ENST00000449288	B1AHR2 [Direct mapping] Neuronal-specific septin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	178 aa 20.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.