Tissue expression of SEPT3 - Summary - The Human Protein Atlas

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SEPT3

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SEPT3
Gene description	Septin 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebral cortex, cerebellum, hippocampus, caudate, hypothalamus)
FANTOM5:	Group enriched (hippocampus, cerebellum, brain, caudate)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in the CNS and cytoplasmic expression in islets of Langerhans.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA003548 , CAB017633
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, cerebellum, hippocampus, caudate, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (hippocampus, cerebellum, brain, caudate)

GENE INFORMATION
Gene name	SEPT3 (HGNC Symbol)
Synonyms	SEP3
Description	Septin 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	41976272 - 41998221
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100167 (version 83.38)
Entrez gene	55964
UniProt	Q9UH03 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UH03
Antibodypedia	SEPT3 antibodies

PROTEIN BROWSER

SEPT3-001	SEPT3-003	SEPT3-004	SEPT3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEPT3-001 ENSP00000379703 ENST00000396425	Q9UH03 [Direct mapping] Neuronal-specific septin-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0007049 [cell cycle] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0051301 [cell division] Show all	350 aa 40.1 kDa	No	0
SEPT3-003 ENSP00000379704 ENST00000396426	Q9UH03 [Direct mapping] Neuronal-specific septin-3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0007049 [cell cycle] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0051301 [cell division] Show all	358 aa 40.7 kDa	No	0
SEPT3-004 ENSP00000383956 ENST00000406029	B1AHR1 [Direct mapping] Neuronal-specific septin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0007049 [cell cycle] Show all	294 aa 33.6 kDa	No	0
SEPT3-006 ENSP00000391416 ENST00000449288	B1AHR2 [Direct mapping] Neuronal-specific septin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] Show all	178 aa 20.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.