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Cancer tissues were generally negative. A few cases of renal cancers displayed moderate cytoplasmic positivity. A few cases in urothelial cancers showed strong cytoplasmic staining.
GENE INFORMATION
Gene name
HMOX1 (HGNC Symbol)
Synonyms
bK286B10, HO-1
Description
Heme oxygenase 1 (HGNC Symbol)
Entrez gene summary
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]