Expression of APOL1 in cancer - Summary

CANCER ATLAS

Gene description

Apolipoprotein L, 1

Protein class

Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA018885	CAB056156

GENE INFORMATION
Gene name	APOL1 (HGNC Symbol)
Synonyms	APOL
Description	Apolipoprotein L, 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	36253010 - 36267530
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100342 (version 83.38)
Entrez gene	8542
UniProt	O14791 (UniProt - Evidence at protein level)
neXtProt	NX_O14791
Antibodypedia	APOL1 antibodies

PROTEIN BROWSER

APOL1-001	APOL1-003	APOL1-009	APOL1-011	APOL1-013	APOL1-201	APOL1-202	APOL1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOL1-001 ENSP00000380448 ENST00000397278	O14791 [Direct mapping] Apolipoprotein L1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006869 [lipid transport] GO:0006898 [receptor-mediated endocytosis] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0019835 [cytolysis] GO:0031224 [intrinsic component of membrane] GO:0031640 [killing of cells of other organism] GO:0034361 [very-low-density lipoprotein particle] GO:0034364 [high-density lipoprotein particle] GO:0042157 [lipoprotein metabolic process] GO:0045087 [innate immune response] GO:0072562 [blood microparticle] GO:1902476 [chloride transmembrane transport] Show all	398 aa 44 kDa	Yes	1
APOL1-003 ENSP00000317674 ENST00000319136	O14791 [Direct mapping] Apolipoprotein L1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006869 [lipid transport] GO:0006898 [receptor-mediated endocytosis] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0019835 [cytolysis] GO:0031224 [intrinsic component of membrane] GO:0031640 [killing of cells of other organism] GO:0034361 [very-low-density lipoprotein particle] GO:0034364 [high-density lipoprotein particle] GO:0042157 [lipoprotein metabolic process] GO:0045087 [innate immune response] GO:0072562 [blood microparticle] GO:1902476 [chloride transmembrane transport] Show all	414 aa 45.9 kDa	No	2
APOL1-009 ENSP00000404525 ENST00000438034	B1AH94 [Direct mapping] Apolipoprotein L1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	118 aa 13 kDa	No	1
APOL1-011 ENSP00000391302 ENST00000427990	B1AH96 [Direct mapping] Apolipoprotein L1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006869 [lipid transport] GO:0008289 [lipid binding] GO:0042157 [lipoprotein metabolic process] Show all	160 aa 18.1 kDa	Yes	0
APOL1-013 ENSP00000392514 ENST00000433768	B1AH95 [Direct mapping] Apolipoprotein L1; cDNA FLJ59906, moderately similar to Apolipoprotein-L1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 15 kDa	Yes	0
APOL1-201 ENSP00000380449 ENST00000397279	O14791 [Direct mapping] Apolipoprotein L1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006869 [lipid transport] GO:0006898 [receptor-mediated endocytosis] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0019835 [cytolysis] GO:0031224 [intrinsic component of membrane] GO:0031640 [killing of cells of other organism] GO:0034361 [very-low-density lipoprotein particle] GO:0034364 [high-density lipoprotein particle] GO:0042157 [lipoprotein metabolic process] GO:0045087 [innate immune response] GO:0072562 [blood microparticle] GO:1902476 [chloride transmembrane transport] Show all	398 aa 44 kDa	Yes	1
APOL1-202 ENSP00000411507 ENST00000422706	O14791 [Direct mapping] Apolipoprotein L1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006869 [lipid transport] GO:0006898 [receptor-mediated endocytosis] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0019835 [cytolysis] GO:0031224 [intrinsic component of membrane] GO:0031640 [killing of cells of other organism] GO:0034361 [very-low-density lipoprotein particle] GO:0034364 [high-density lipoprotein particle] GO:0042157 [lipoprotein metabolic process] GO:0045087 [innate immune response] GO:0072562 [blood microparticle] GO:1902476 [chloride transmembrane transport] Show all	398 aa 44 kDa	Yes	1
APOL1-203 ENSP00000388477 ENST00000426053	O14791 [Direct mapping] Apolipoprotein L1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006869 [lipid transport] GO:0006898 [receptor-mediated endocytosis] GO:0008203 [cholesterol metabolic process] GO:0008289 [lipid binding] GO:0019835 [cytolysis] GO:0031224 [intrinsic component of membrane] GO:0031640 [killing of cells of other organism] GO:0034361 [very-low-density lipoprotein particle] GO:0034364 [high-density lipoprotein particle] GO:0042157 [lipoprotein metabolic process] GO:0045087 [innate immune response] GO:0072562 [blood microparticle] GO:1902476 [chloride transmembrane transport] Show all	380 aa 42.2 kDa	Yes	0