Expression of PHF5A in cancer - Summary

CANCER ATLAS

Gene description

PHD finger protein 5A

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028885

GENE INFORMATION
Gene name	PHF5A (HGNC Symbol)
Synonyms	bK223H9.2, INI, MGC1346, Rds3, SAP14b, SF3b14b, SF3B7
Description	PHD finger protein 5A (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	41459717 - 41468725
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100410 (version 83.38)
Entrez gene	84844
UniProt	Q7RTV0 (UniProt - Evidence at protein level)
neXtProt	NX_Q7RTV0
Antibodypedia	PHF5A antibodies

PROTEIN BROWSER

PHF5A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHF5A-001 ENSP00000216252 ENST00000216252	Q7RTV0 [Direct mapping] PHD finger-like domain-containing protein 5A A0A024R1U2 [Target identity:100%; Query identity:100%] PHD finger protein 5A, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005686 [U2 snRNP] GO:0005689 [U12-type spliceosomal complex] GO:0006351 [transcription, DNA-templated] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0016363 [nuclear matrix] GO:0016607 [nuclear speck] GO:0044822 [poly(A) RNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0071011 [precatalytic spliceosome] GO:0071013 [catalytic step 2 spliceosome] Show all	110 aa 12.4 kDa	No	0